Liquid biopsy is an important method for the diagnosis of lung cancer,and compared with traditional tissue biop-sy,liquid biopsy has the advantages of favorable safety,noninvasiveness,convenience in obtaining specimens,and dynamic moni-toring.Therefore,it has a marked value in the diagnosis of early-stage lung cancer.This article summarizes the research advances in liquid biopsy in the diagnosis of early-stage lung cancer in China and globally and discusses its value in the diagnosis of early-stage lung cancer.