外泌体在弥漫大B细胞淋巴瘤中的研究进展
Research advances in exosomes in diffuse large B-cell lymphoma
陈师旅 1吴春燕 1顾华丽 2吴少玲1
作者信息
- 1. 青岛大学附属医院血液内科,山东青岛 266003
- 2. 青岛大学附属医院急诊内科,山东青岛 266003
- 折叠
摘要
弥漫大B细胞淋巴瘤(DLBCL)作为一种异质性极强的侵袭性B细胞淋巴瘤,治疗后可能面临复发难治的问题.外泌体作为细胞外囊泡(EVs)以及液体活检的一份子,其本身及分泌的小分子物质在肿瘤中发挥沟通及调节的作用.深入了解外泌体与DLBCL发展、耐药及预后的关系,将会为DLBCL的诊治提供新的思路.本文综述了近几年外泌体与DLBCL研究的最新进展.
Abstract
Diffuse large B-cell lymphoma(DLBCL)is a highly heterogeneous and aggressive B-cell lymphoma,and there are still the problems of recurrence and refractory disease after treatment.Exosomes,as a part of extracellular vesicles(EVs)and li-quid biopsy,and the small molecules secreted by them play a role of communication and regulation in tumor microenvironment.A deep understanding of the association of exosomes with the development,drug resistance,and prognosis of DLBCL may provide new ideas for the diagnosis and treatment of DLBCL.This article reviews the latest research advances in exosomes and DLBCL.
关键词
外泌体/淋巴瘤,大B细胞,弥漫性/综述Key words
exosomes/lymphoma,large B-cell,diffuse/review引用本文复制引用
基金项目
山东省自然科学基金(ZR2019MH096)
出版年
2024
国家科技期刊平台
NSTL
万方数据