Objective To investigate the association between mean platelet volume-to-lymphocyte ratio(MPVLR)and up-per gastrointestinal bleeding(UGIB)in patients with peptic ulcer(PU).Methods A total of 233 patients with PU who were diagnosed and treated in Anyang People's Hospital from June 2021 to June 2023 were enrolled as study group,and 210 healthy in-dividuals who underwent physical examination during the same period of time were enrolled as control group.Mean platelet volume(MPV)and lymphocyte count(LYM)were measured within 24 hours after admission,and MPVLR was calculated.According to the presence or absence of UGIB during follow-up,the patients with PU were divided into UGIB group with 72 patients and non-UGIB group with 161 patients.The receiver operating characteristic(ROC)curve was used to assess the value of MPVLR in the diagnosis of PU complicated by UGIB,and the multivariate Logistic regression analysis was used to investigate the risk factors for PU complicated by UGIB.Results The study group had a significantly higher MPVLR than the control group(t=70.287,P＜0.05),and the UGIB group had a significantly higher MPVLR than the non-UGIB group(t=26.566,P＜0.05).The ROC curve analysis showed that MPVLR had an area under the ROC curve of 0.741(95％CI=0.761-0.861)in the diagnosis of UGIB in pa-tients with PU.The multivariate Logistic stepwise regression analysis showed that the use of nonsteroidal anti-inflammatory drugs(OR=2.423,95％CI=1.650-3.558,P＜0.05),Helicobacter pylori infection(OR=3.047,95％CI=1.802-5.151,P＜0.05),and MPVLR(OR=3.762,95％CI=2.001-7.072,P＜0.05)were risk factors for PU complicated by UGIB.Conclusion There is an abnormal increase in MPVLR in patients with PU,with has a high predictive value for UGIB.
维普
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