Objective To investigate the dynamic changes of serum regulatory T cells(Treg),lactate(Lac),and adiponec-tin(APN)and their association with disease severity in children with sepsis.Methods A retrospective analysis was performed for the case data of 138 children with sepsis who were admitted to our hospital from January 2023 to June 2024,and according to disease severity,they were divided into mild-to-moderate group with 60 children and severe group with 78 children.According to the prognosis within 7 days,the severe group was further divided into survival group with 63 children and death group with 15 chil-dren.The serum levels of Treg,Lac,and APN at different time points were compared between groups,and the children in the se-vere group were analyzed in terms of the correlation of the serum levels of Treg,Lac,and APN on admission with Acute Physiolo-gy and Chronic Health Evaluation Ⅱ(APACHE Ⅱ)score.Results Compared with the mild-to-moderate group,the severe group had significant increases in the serum levels of Treg and Lac and a significant reduction in the serum level of APN on admis-sion and at 24 and 48 hours after admission(F=6.892-10.623,P＜0.001),and compared with the survival group,the death group had significantly higher serum levels of Treg and Lac and a significantly lower serum level of APN at each time point(F=7.253-12.744,P＜0.001).For the children in the severe group,the serum levels of Treg and Lac on admission were significantly positively correlated with APACHE Ⅱ score(r=0.857,0.912,P＜0.01),while the serum level of APN was significantly negative-ly correlated with APACHE Ⅱ score(r=-0.886,P＜0.01).Conclusion The serum levels of Treg,Lac,and APN are corre-lated with disease severity in children with severe sepsis.
维普
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