Objective To investigate the clinical effect of interventional recanalization therapy in the treatment of non-acute symptomatic intracranial large artery occlusion.Methods A total of 200 patients with non-acute symptomatic intracranial large artery occlusion who were admitted to Hengshui People's Hospital,The Sixth People's Hospital of Hengshui,The Second Hospi-tal of Hebei Medical University,and Hebei General Hospital from August 2021 to August 2023 were enrolled as subjects,among whom 100 patients treated with medication were enrolled as control group and 100 patients treated with interventional recanaliza-tion therapy were enrolled as treatment group.Treatment outcome was compared between the two groups.Results The treat-ment group achieved a vascular recanalization rate of 98%after surgery.There was a significant difference in National Institutes of Health Stroke Scale(NIHSS)score across different times before and after treatment in each group(F=101.984,971.202,P<0.05).Both groups had a significant reduction in NIHSS score after 1,3,and 6 months of treatment(P<0.05),and the treatment group had a significantly lower score than the control group(F=5.782-8.497,P<0.05).Compared with the control group,the treatment group had a significantly higher proportion of patients with a modified Rankin Scale score of ≤2 at 3 and 6 months after surgery(X2=4.348,9.072,P<0.05)and a significantly lower recurrence rate(X2=3.097,P<0.05).Conclusion Interventio-nal recanalization therapy for non-acute symptomatic intracranial large artery occlusion can achieve a relatively high vascular reca-nalization rate and effectively improve the neurological function and prognosis of patients.