Objective To investigate the efficacy and safety of thrombopoietin receptor agonists(TPO-RA)in the treatment of children with primary immune thrombocytopenia(ITP).Methods Clinical data were collected from 16 children with ITP who had no response to the first-line treatment including glucocorticoids and immunoglobulin,experienced disease recurrence,and re-ceived oral administration of TPO-RA,and they were monitored in terms of platelet count(PLT),bleeding grade,and adverse events before and after treatment.Results All 16 children showed a significant change in PLT after 1,2,and 3 weeks and 1,2,3,and 4 months of administration(Z=2.261 to 3.408,P＜0.05),and there was a significant improvement in bleeding grade after treatment(Z=-2.140,P＜0.05).Adverse events during treatment were mostly mild or moderate,and the children were to-lerant to these adverse events,with no serious adverse events during treatment.Conclusion TPO-RA has good efficacy,high safety,and good tolerability in children with ITP.
关键词
血小板生成素受体激动剂/儿童/紫癜,血小板减少性,特发性/治疗结果/药物相关性副作用和不良反应
Key words
thrombopoietin receptor agonists/child/purpura,thrombocytopenic,idiopathic/treatment outcome/drug-re-lated side effects and adverse reactions
维普
万方数据