强激光与粒子束2025,Vol.37Issue(1) :91-97.DOI:10.11884/HPLPB202537.240367

一种±5 kV双极性直线型变压器驱动源设计及其在电穿孔中的应用

Design of a±5 kV bipolar linear transformer driver and its application in cell electroporation

李响 周伟康 王坤
强激光与粒子束2025,Vol.37Issue(1) :91-97.DOI:10.11884/HPLPB202537.240367

一种±5 kV双极性直线型变压器驱动源设计及其在电穿孔中的应用

Design of a±5 kV bipolar linear transformer driver and its application in cell electroporation

李响 1周伟康 1王坤1
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作者信息

  • 1. 河北工业大学省部共建电工装备可靠性与智能化国家重点实验室,天津 300401
  • 折叠

摘要

提出了一种双极性直线型变压器驱动源布局结构,实现了双极性直线型变压器驱动源模块的灵活叠加.通过调节驱动电路的驱动电压来调控金属氧化物半导体场效应晶体管的导通时间,精确控制脉冲电压的上升时间.在直线型变压器驱动源结构中引入了磁芯-铜柱一体结构和反向过冲泄放回路,优化了电磁兼容性,减小了脉冲波尾的反向过冲.研制的双极性直线型变压器驱动源在1 kHz的频率下能够稳定输出脉冲宽度为1μs、幅值为±5 kV的脉冲电压,上升时间从30ns到100ns内连续可调.利用研制的双极性直线型变压器驱动源开展了细胞不可逆电穿孔实验.

Abstract

This paper proposes a layout structure of the pulsed power generator based on the bipolar linear transformer driver,achieving flexible stacking of the bipolar linear transformer driver modules.The conduction time of the metal-oxide-semiconductor field effect transistor is regulated by adjusting the voltage of the driver circuit,enabling precise control over the rise time of the pulsed voltage.An integrated core-copper pillar structure and a reverse overshoot discharge circuit are introduced in the linear transformer driver structure,which optimizes the electromagnetic compatibility and reduces the reverse overshoot at the tail of the pulsed waveform.The developed bipolar linear transformer driver device can stably output±5 kV pulsed voltage with 1 kHz frequency and 1 μs pulse width.The rise time of the pulsed voltage is continuously adjustable from 30 ns to 100 ns.The irreversible electroporation experiments on cells are carried out using the bipolar linear transformer driver.

关键词

直线型变压器驱动源/双极性/纳秒脉冲/不可逆电穿孔

Key words

linear transformer driver/bipolar/nanosecond pulse/irreversible electroporation

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出版年

2025
强激光与粒子束
中国工程物理研究院 中国核学会 四川核学会

强激光与粒子束

CSTPCDCSCD北大核心
影响因子:1.008
ISSN:1001-4322
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