Effect of transdermal estrogenic endometrial preparation on pregnancy outcome of frozen-thawed embryo trans-fer in patients with unexplained recurrent implantation failure
Effect of transdermal estrogenic endometrial preparation on pregnancy outcome of frozen-thawed embryo trans-fer in patients with unexplained recurrent implantation failure
Objective To investigate the effect of different endometrial preparation methods on the clinical pregnancy outcomes of frozen-thawed embryo transfer(FET)for unexplained recurrent implantation failure(URIF).Methods To-tally 94 patients with URIF were included and divided into the experimental group(33 cases)and control group(61 cases)according to the different method of endothelial preparation.The experimental group received transdermal estrogen gel,and the control group received oral 17β-oestradiol.The effects of different endo-preparation regimens on clinical pregnancy outcomes in unexplained recurrent implantation failure were compared.Results The estradiol level on the day of conversion in the experimental group was significantly higher than that in the control group(t=2.92,P＜0.05),and the differences in the number of embryos transferred,the number of high-quality embryos,and the implantation rate were statistically significant(Z=3.65,3.67,χ2 =6.07,P＜0.05).However,there were no significant differences in the pro-geserone level and endometrial thickness on the day of conversion,clinical pregnancy rate,multiple pregnancy rate,mis-carriage rate,and live birth rate between the two groups(Z=1.19,t=0.85,χ2=3.22,0.85,0.03,1.78,P＞0.05).Conclu-sion Different methods of endometrial preparation had no significant effect on clinical pregnancy outcomes in FET with URIF.
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