Objective To analyze whether YRDC gene has the expression characteristics of proto oncogene in colorec-tal cancer,its correlation with clinicopathological parameters and its influence on prognosis.Methods A total of 156 pa-tients diagnosed with colorectal cancer were selected.The expression level of YRDC in cancer tissue and adjacent tissue samples was detected by immunohistochemistry.The correlation between clinical parameters and YRDC expression was an-alyzed.Kaplan-Meier method was used to draw the survival curve of patients,and COX model was used to analyze the factors of the prognosis of patients with colorectal cancer.Results The expression of YRDC protein in colorectal cancer tissue was significantly higher than that in adjacent tissues,and the difference was statistically significant(χ2=143.22,P＜0.05).The survival period of patients with high expression of YRDC was significantly shorter than that of patients with low expression,and the 1-year survival rate and last follow-up survival rate were lower than those of patients with low expression.The recurrence and metastasis rate was higher than that of patients with low expression,and the differences were statistically significant(t=40.13,χ2=6.91,7.81,8.12,P＜0.05).COX regression analysis showed that distant metasta-sis,carcinoembryonic antigen,and YRDC expression were independent influencing factors of the survival outcome of colorectal cancer patients(OR=3.13,34.75,2.22,P＜0.05).Conclusion The high level expression of YRDC often pre-dicts poor prognosis and may become a potential biomarker to judge the prognosis of colorectal cancer patients,which is helpful to further find the target of molecular therapy for colorectal cancer.
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