Objective To explore the application value of NoSAS score in identifying high-risk groups for hypoxemia during deep sedation bronchoscopy.Methods Totally 293 patients who underwent deep sedation bronchoscopy were se-lected as the subjects.Patients were divided into obstructive sleep apnea syndrome(OSAS)high-risk group and OSAS low-risk group according to NoSAS score.The incidence of cardiopulmonary adverse events such as hypoxemia and air-way intervention rates between two groups of patients during deep sedation bronchoscopy were compared.Univariate analy-sis and multivariate logistic regression analysis were conducted on the influencing factors of hypoxemia.Results Com-pared with the low-risk group,the high-risk group had a higher frequency of hypoxemia,severe hypoxemia,and airway intervention(jaw lift,increase the flow of oxygen,bag-mask ventilation),and the differences were statistically significant(χ2=8.47,5.51,14.36,4.52,8.48,P<0.05).Logistic multivariate analysis further showed that the high-risk group signifi-cantly increased the risk of hypoxemia during deep sedation bronchoscopy when compared to the low-risk group,with sta-tistical significance(OR= 2.38,95%CI 1.28-4.43,P<0.05).Conclusion The NoSAS score helps to identify high-risk groups for hypoxemia during deep sedation bronchoscopy,and provid a valuable evidence for active prevention and inter-vention of hypoxemia.