Objective To explore and evaluate the predictive efficacy of skeletal muscle mass and muscle strength in 3-month neurological prognosis in patients with ischemic stroke.Methods A total of 117 stroke patients were included.According to the modified Rankin scale(mRS)score after stroke,all patients were divided into the poor prognosis group(54 cases)and the good prognosis group(63 cases).Skeletal muscle mass and muscle strength were compared between two groups.The correlation between the above indicators and the mRS score was analyzed by pearson correlation.And lo-gistic regression was used to analyze the relationship between ASM/Ht2,grip strength and neurological prognosis,while ap-plying ROC curves to assess their predictive efficacy on neurological prognosis.Results Compared with the good prog-nosis group,the poor prognosis group was older,had a higher median NIHSS score,a higher proportion of patients with low muscle mass,low muscle strength,and both low muscle mass and low muscle strength(t=3.55,4.94,χ2=7.27,20.35,11.51,P＜0.05).Meanwhile,there were a lower ASM/Ht2,and a lower grip strength in the poor prognosis group,with sta-tistically significant(t=-4.40,-9.56,P＜0.05).After adjusting for age,sex,and BMI,ASM/Ht2 and grip strength were negatively correlated with mRS(r=-0.56,-0.74,P＜0.05).Multivariate logistic regression analysis found that both higher ASM/Ht2 and grip strength were in-dependent protective factors for the poor neurologi-cal outcome(OR= 0.64,0.54,P＜0.05).ROC analysis showed that the AUC of grip strength was the 0.89,which was significantly greater than the AUC of ASM/Ht2(0.71)(Z=3.05,P＜0.05).Conclusion The skeletal muscle mass and muscle strength in the ear-ly stage of stroke patients are closely related to their poor neurological prognosis in the rehabilitation period.Both skel-etal muscle mass and muscle strength have a good predictive value for neurological function prognosis in stroke pa-tients,especially for handgrip strength,which has a better predictive efficacy.
维普
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