摘要
目的 探讨加味桂枝茯苓丸在慢性盆腔炎(湿热瘀结型)患者治疗中的应用价值,观察其对炎症因子、免疫功能的影响.方法 将慢性盆腔炎(湿热瘀结型)患者96 例纳入研究,随机分为两组,各48 例.对照组采用西医常规治疗,观察组联合加味桂枝茯苓丸治疗,治疗4 周,比较两组临床疗效.结果 治疗后,观察组血清白介素-6(IL-6)、血清单核细胞趋化蛋白-1(MCP-1)、粒细胞-巨噬细胞集落刺激因子(GM-CSF)、糖类抗原CA125(CA125)、D二聚体(D-D)、转化生长因子-β1(TGF-β1)低于对照组(t分别=-11.92、-14.61、-9.82、-9.28、-12.91、-10.28,P均＜0.05);白介素-10(IL-10)、CD4+/CD8+、CD4+及CD3+均高于对照组(t分别=9.18、8.06、8.16、9.06,P均＜0.05).观察组治疗总有效率93.75%高于对照组的75.00%,差异有统计学意义(χ2=6.40,P＜0.05);两组不良反应发生率比较,差异无统计学意义(χ2=0.06,P＞0.05).结论 联合加味桂枝茯苓丸治疗慢性盆腔炎(湿热瘀结型)患者可减轻炎症反应,改善高凝状态,抗纤维化,且不良反应小.
Abstract
Objective To explore the application value of Jiawei Guizhi Fuling Pill in the treatment of patients with chronic pelvic inflammatory disease(dampness heat stasis type),and observe its effects on inflammatory factors and im-mune function.Methods A total of 96 patients with chronic pelvic inflammatory disease were included and randomly divided into two groups using a random number table method,with 48 patients in each group.The control group was treat-ed with conventional western medicine,while the observation group was treated with modified Guizhi Fuling pills on ba-sis of conventional treatment for 4 weeks.The clinical efficacy of the two groups was compared.Results After treatment,serum interleukin-6(IL-6),serum monocyte chemotactic protein-1(MCP-1),granulocyte-macrophage colony-stimulat-ing factor(GM-CSF),glycan antigen CA125(CA125),D-dimer(D-D),and transforming growth factor-beta 1(TGF-β 1)were lower in the observation group than in the control group(t=-11.92,-14.61,-9.82,-9.28,-12.91,-10.28,P＜0.05).The interleukin-10(IL-10),CD4+/CD8+,CD4+ and CD3+ levels were higher than the control group(t=9.18,8.06,8.16,9.06,P＜0.05).The total effective rate of the observation group was 93.75%,which was higher than 75.00%of the control group(χ2=6.40,P＜0.05).The incidence of adverse reactions in the observation group and control group was not statistically significant(χ2=0.06,P＞0.05).Conclusion For patients with chronic pelvic inflammatory disease(damp-ness heat stasis type),the combination of Jiawei Guizhi Fuling pill can reduce inflammatory reactions,improve hypercoag-ulability,resist fibrosis,and have fewer adverse reactions.
维普
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