摘要
目的 探讨2型糖尿病合并超重肥胖患者血清25羟维生素D[25(OH)D]、尿微量白蛋白(UMA)水平变化及临床意义.方法 回顾性分析96例2型糖尿病患者的资料,根据体重指数将2型糖尿病患者分为超重肥胖组(n=42例)和正常组(n=54例).比较两组患者临床特征和实验室指标,采用Pearson相关性分析25(OH)D和UMA水平与实验室指标的关系,采用线性回归分析影响25(OH)D和UMA水平变化因素.结果 超重肥胖组患者体重指数、蛋白质摄入、脂肪摄入、腰臀比、血清甘油三酯、总胆固醇、UMA水平均高于正常组患者(t分别=17.26、2.33、2.92、6.84、9.67、4.20、17.26,P均＜0.05),超重肥胖组患者25(OH)D水平低于正常组患者(t=-20.89,P＜0.05);体重指数、蛋白质摄入、脂肪摄入、腰臀比、甘油三酯、总胆固醇均与25(OH)D水平呈负相关(r分别=-0.54、-0.44、-0.48、-0.50、-0.53、-0.37,P均＜0.05),体重指数、蛋白质摄入、脂肪摄入、腰臀比、糖化血红蛋白、甘油三酯、总胆固醇均与UMA水平呈正相关(r分别=0.51、0.41、0.46、0.49、0.28、0.48、0.34,P均＜0.05);体重指数、腰臀比、甘油三酯均是25(OH)D水平的影响因素(t分别=7.56、6.28、4.62,P均＜0.05),体重指数、腰臀比均是UMA水平的影响因素(t分别=7.05、6.29,P均＜0.05).结论 2型糖尿病合并超重肥胖患者UMA水平异常升高,25(OH)D水平异常降低,25(OH)D、UMA水平变化与体重指数、腰臀比有关,二者可能在2型糖尿病合并超重肥胖发病机制中起一定作用.
Abstract
Objective To investigate the changes and clinical significance of serum levels of 25(OH)D and urinary microalbumin(UMA)in type 2 diabetes mellitus patients with overweight and obesity.Methods The data of 96 pa-tients with type 2 diabetes mellitus were analyzed retrospectively,according to body mass index,patients with type 2 dia-betes mellitus were divided into overweight and obesity group(42 cases)and normal group(54 cases).The clinical char-acteristics and laboratory indicators of the two groups were compared.Pearson correlation was used to analyze the relation-ship between 25(OH)D and UMA levels and laboratory indicators.Line regression was used to analyze the factors affect-ing the changes of 25(OH)D and UMA levels.Results The body mass index,protein intake,fat intake,waist-to-hip ra-tio,serum triglyceride,total cholesterol and UMA levels in the overweight and obesity group were higher than those in the normal group(t=17.26,2.33,2.92,6.84,9.67,4.20,17.26,P＜0.05),and the 25(OH)D level in the overweight and obesity group was lower than that in the normal group(t=-20.89,P＜0.05).Body mass index,protein intake,fat intake,waist-to-hip ratio,triglyceride and total cholesterol were negatively correlated with 25(OH)D level(r=-0.54,-0.44,-0.48,-0.50,-0.53,-0.37,P＜0.05),while body mass index,protein intake,fat intake,waist-to-hip ratio,glycosylated hemoglo-bin,triglyceride and total cholesterol were positively correlated with UMA level(r=0.51,0.41,0.46,0.49,0.28,0.48,0.34,P＜0.05).Body mass index,waist to hip ratio and triglyceride were all the influencing factors of 25(OH)D level(t=7.56,6.28,4.62,P＜0.05),and body mass index and waist to hip ratio were all the influencing factors of UMA level(t=7.05,6.29,P＜0.05).Conclusion The level of UMA in type 2 di-abetes mellitus patients with overweight and obesity is abnormally high,and the level of 25(OH)D is abnormally low.The changes of 25(OH)D and UMA levels are related to body mass index and waist hip ratio,which may play a role in the pathogenesis of type 2 diabetes patients with overweight and obesity.
维普
万方数据