GLUT1在肝癌炎症性贫血患者中的表达及临床意义
Expression and clinical significance of GLUT1 in hepatocellular carcinoma patients with inflammatory anemia
洪淑芳 1杜晓明 1杨益敏 2李凯强2
作者信息
- 1. 321000 浙江金华,金华市中心血站,金华市输血研究所
- 2. 浙江省人民医院(杭州医学院附属人民医院)输血科
- 折叠
摘要
目的 探讨促葡萄糖转运蛋白1(GLUT1)在肝癌炎症性贫血患者血清中的表达,分析其临床意义.方法 收集84 例肝癌住院患者,选取其中C-反应蛋白(CRP)高表达的患者72 例,根据血红蛋白(Hb)水平分为贫血组和非贫血组.采用酶联免疫吸附试验(ELISA)检测患者血清中GLUT1、铁调素和白细胞介素-6(IL-6)表达水平.分析GLUT1与肝癌炎症性贫血的关系.结果 CRP高表达的肝癌患者中贫血发生率为43.06%(31/72).贫血组血清中GLUT1、CRP、IL-6和铁调素表达水平均高于非贫血组(U分别=323.00、459.00、312.50、336.00,P均＜0.05).GLUT1 与Hb呈负相关,与CRP、IL-6 和铁调素均呈正相关,差异均有统计学意义(r分别=-0.50、0.56、0.61、0.60,P均＜0.05).结论 GLUT1过度表达可能在肝癌患者炎症性贫血中发挥重要作用.
Abstract
Objective To investigate the expression and the clinical significance of glucose transporter 1(GLUT1)in serum of hepatocellular carcinoma patients with inflammatory anemia.Methods Totally 84 patients with hepatocellular carcinoma were collected,and 72 patients with high expression of C-reactive protein(CRP)were selected and divided into anemia group and non-anemia group according to hemoglobin(Hb)level.The expression levels of GLUT1,hepcidin and interleukin-6(IL-6)in serum were detected by enzyme-linked immunosorbent assay(ELISA).The relationship be-tween GLUT1 and inflammatory anemia of hepatocellular carcinoma was analyzed.Results The anemia incidence rate in patients with high CRP expression was 43.06%(31/72).The expression levels of GLUT1,CRP,IL-6 and hepcidin in serum of anemia group were higher than those of non-anemia group(U=323.00,459.00,312.50,336.00,P＜0.05).GLUT1 was negatively correlated with Hb,and positively correlated with CRP,IL-6 and hepcidin,all with statistical sig-nificance(r=-0.50,0.56,0.61,0.60,P＜0.05).Conclusion Over-expression of GLUT1 may play an important role in patients with liver cancer and inflammatory anemia.
关键词
肝癌/炎症性贫血/促葡萄糖转运蛋白1/白细胞介素-6/铁调素Key words
hepatocellular carcinoma/inflammatory anemia/glucose transporter 1/interleukin-6/hepcidin引用本文复制引用
基金项目
浙江省医药卫生科技计划(2013ZL010)
出版年
2024
NETL
NSTL
万方数据