摘要
目的 研究子宫内膜异位症患者血清糖蛋白抗原125(CA125)、甲壳质酶蛋白40(YKL-40)、血清人附睾蛋白4(HE4)与临床分期及痛经程度的相关性.方法 选取100 例子宫内膜异位症患者,根据r-AFS分期分为Ⅰ期20 例、Ⅱ期35 例、Ⅲ期28 例、Ⅳ期17 例.痛经程度评估采用视觉疼痛模拟评分(VAS),根据VAS评分将患者分为无疼痛15 例、轻度26 例、中度37 例、重度22 例.比较不同临床分期患者血清CA125、YKL-40、HE4水平;比较不同痛经程度患者血清CA125、YKL-40、HE4水平;采用Spearman相关性分析观察患者血清CA125、YKL-40、HE4水平与临床分期及痛经程度的相关性.结果 不同临床分期子宫内膜异位症患者血清CA125、YKL-40、HE4比较,差异均有统计学意义(F分别=195.08、167.07、166.89,P均＜0.05).不同痛经程度子宫内膜异位症患者血清CA125、YKL-40、HE4比较,差异均有统计学意义(F分别=116.36、142.14、117.18,P均＜0.05).患者血清CA125、YKL-40、HE4水平与临床分期及痛经程度呈正相关(rs分别=0.90、0.92、0.91;0.89、0.90、0.88,P均＜0.05).结论 子宫内膜异位症患者血清CA125、YKL-40、HE4与临床分期及痛经程度呈显著正相关,可考虑将其作为临床辅助诊断、评估子宫内膜异位症病情的生物学指标.
Abstract
Objective To study the correlation of serum CA125,YKL-40,HE4 with clinical stage and dysmenorrhea degree in patients with endometriosis.Methods A total of 100 endometriosis patients were selected as the study group.According to r-AFS stage,20 patients in stage Ⅰ,35 patients in stage Ⅱ,28 patients in stage Ⅲ,and 17 patients in stage Ⅳ.According to the VAS,15 cases without pain,26 cases in mild,37 cases in moderate,and 22 cases in severe.Se-rum LEVELS of CA125,YKL-40 and HE4 in patients with different clinical stages and degrees of dysmenorrhea were compared.Spearman correlation analysis was conducted to observe the correlation between serum CA125,YKL-40,HE4 levels and clinical stage and dysmenorrhea degree.Results The differences in serum CA125,YKL-40,and HE4 levels among patients with endometriosis at different clinical stages were statistically significant(F=195.08,167.07,166.89,P＜0.05).The serum levels of CA125,YKL-40,and HE4 in patients with endometriosis of different degrees of dysmenorrhea were statistically different(F=116.36,142.14,117.18,P＜0.05).The serum levels of CA125,YKL-40,and HE4 in pa-tients were positively correlated with clinical stage and degree of dysmenorrhea(rs=0.90,0.92,0.91;0.89,0.90,0.88,P＜0.05).Conclusion Serum CA125,YKL-40 and HE4 in patients with endometriosis were significantly positively cor-related with clinical stage and dysmenorrhea degree,which could be considered as biological indicators for clinical diag-nosis and evaluation of endometriosis.
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