Objective To investigate the correlation between vitamin D levels in postmenopausal women and COVID-19-related symptoms.Methods A total of 65 postmenopausal female patients were selected.The age,serum vitamin D levels,and COVID-19 related symptoms were collected for analysis.The correlation between vitamin D levels in post-menopausal women and COVID-19 related symptoms was analyzed.Results The average age of the 65 patients was(61.97±8.11)years,with an average serum vitamin D level of(24.71±7.22)ng/mL.Vitamin D deficiency was observed in 30.77%patients.The average number of chronic diseases per patient was(1.03±0.73).The mean duration of illness after contracting COVID-19 was(12.66±4.00)days,with an average number of fever days being(4.34±1.22).The high-est recorded body temperature averaged at(39.60±0.40)℃,while the lowest blood oxygen saturation level measured at(96.75±1.92)%.Patients experienced an average of 1(1,1)respiratory symptoms,followed by 1(1,0)digestive system symptoms,and then by 0(1,0)circulatory system symptoms.Neurological symptoms were reported to be present in an average of 1(1,1).Vitamin D levels showed a positive correlation with age(r=0.31,P<0.05),and negative correlations with COVID-19 duration,number of fever days,and total number of symptoms associated with COVID-19(r=-0.55,-0.60,-0.69,P<0.05),respectively.Vitamin D level also exhibited a positive correlation with the lowest blood oxygen satura-tion level after contracting COVID-19(r=0.45,P<0.05).Conclusion Vitamin D level is associated with the severity of COVID-19 symptoms in postmenopausal women.Maintaining higher vitamin D level may promote improvement in re-lated symptoms among COVID-19 patients.