卵巢储备功能减退的年轻不孕症女性代谢综合征发生情况分析
Analysis of metabolic syndrome in young women with infertility and diminished ovarian reserve
陆月红 1何尧 2夏舟岚1
作者信息
- 1. 312000 浙江绍兴,绍兴市妇幼保健院生殖科
- 2. 312000 浙江绍兴,绍兴市妇幼保健院妇科
- 折叠
摘要
目的 探究代谢综合征(MS)在卵巢储备功能减退(DOR)的年轻不孕症女性中的发生情况并分析其影响因素.方法 共纳入141名合并DOR的年轻不孕症女性(年龄＜35 岁),设为DOR组,另外选取141名与DOR组年龄配对且卵巢储备功能正常(NOR)的不孕症女性作为对照组(NOR组).比较两组患者MS的发生情况并分析DOR组MS发生的影响因素.结果 DOR组MS发病率明显高于NOR组,差异有统计学意义(χ2=8.25,P＜0.05).logistic多因素分析发现,高FSH/LH比值为年轻不孕症女性合并DOR发生MS的独立危险因素(OR=1.26,P＜0.05),而高AMH、高bLH和高bE2水平为DOR年轻不孕症女性发生MS的保护因素(OR分别=0.28、0.58、0.86,P均＜0.05).结论 年轻不孕症女性中,合并DOR者MS的发病率明显升高,FSH/LH、AMH、bLH、bE2为发生MS的影响因素.
Abstract
Objective To investigate the incidence of metabolic syndrome(MS)in young women with infertility and diminished ovarian reserve(DOR)and analyze its influencing factors.Methods A total of 141 young women with infer-tility and DOR(age＜35 years)were enrolled as DOR group,and another 141 young women(age-matched with DOR)with infertility and normal ovarian reserve function(NOR)group were selected as control group(NOR group).The occur-rences of MS were compared between the two groups and the influencing factors were analyzed.Results The incidence of MS in DOR group was significantly higher than that in NOR group(χ2=8.25,P＜0.05).Logistic multivariate analysis showed that high FSH/LH ratio was an independent risk factor for MS in young women with infertility complicated with DOR(OR=1.26,P＜0.05),while high AMH,basal LH and basal E2 levels were protective factors for MS(OR=0.28,0.58,0.86,P＜0.05).Conclusion In young women with infertility and DOR,the incidence of MS is significantly in-creased.The FSH/LH ratio,AMH,bLH,and bE2 are influencing factors for MS in young women with infertility complicat-ed with DOR.
关键词
卵巢储备功能减退/心血管疾病/代谢紊乱/代谢综合征Key words
diminished ovarian reserve/cardiovascular risk/metabolic disturbances/metabolism syndrome引用本文复制引用
基金项目
2021年浙江省卫生健康面上项目(2021KY1154)
绍兴市科技计划项目(2022A14005)
出版年
2024
NETL
NSTL
万方数据