摘要
目的 比较双相情感障碍Ⅱ型(BD-Ⅱ)与重度抑郁障碍(MDD)患者炎症细胞因子、T淋巴细胞亚群水平.方法 选取40 例BD-Ⅱ患者为BD-Ⅱ组,同期选取40 例MDD患者为MDD组.在患者入院后24h内,采用汉密尔顿抑郁量表(HAMD-24)、轻躁狂症状量表(HCL-32)、自杀意念自评量表(SIOSS)评估两组患者的抑郁、躁狂状态和自杀意念情况,比较两组白介素-6(IL-6)、白介素-4(IL-4)、白介素-1β(IL-1β)、CD3+、CD4+、CD8+、CD4+/CD8+水平.采用Pearson相关性分析BD-Ⅱ和MDD患者炎症细胞因子、T淋巴细胞亚群计数水平与抑郁、躁狂状态和自杀意念的相关性.结果 BD-Ⅱ组的HAMD-24、HCL-32、SIOSS量表得分均高于MDD组(t分别=2.20、10.00、2.71,P均＜0.05).两组血清IL-1β水平比较,差异无统计学意义(t=1.57,P＞0.05).BD-Ⅱ组的血清IL-6、IL-4水平均高于MDD组(t分别=8.88、3.60,P均＜0.05).两组CD4+/CD8+比较,差异无统计学意义(t=1.10,P＞0.05);BD-Ⅱ组CD3+、CD4+、CD8+水平均高于MDD组(t分别=2.83、2.64、2.68,P均＜0.05).BD-Ⅱ患者的血清IL-6、IL-4、CD3+、CD4+、CD8+与HAMD-24、HCL-32、SIOSS量表均呈正相关(P均＜0.05).MDD患者的血清IL-6、IL-4、CD3+、CD4+、CD8+与HAMD-24、HCL-32、SIOSS量表均呈正相关(P均＜0.05).结论 相比较于MDD患者,BD-Ⅱ患者的血清IL-6、IL-4水平和CD3+、CD4+、CD8+水平更高,与抑郁、躁狂状态和自杀意念评分具有正相关性.
Abstract
Objective To compare inflammatory cytokines and T lymphocyte subsets in patients with bipolar disorder type Ⅱ(BD-Ⅱ)and major depressive disorder(MDD).Methods A total of 40 patients with BD-Ⅱ and 40 patients with MDD were enrolled as BD-Ⅱ group and MDD group,respectively.Within 24h after admission,depression,mania state and suicide idea of patients were evaluated by Hamilton depression scale-24(HAMD-24),hypomania checklist-32(HCL-32)and self-rating idea of suicide scale(SIOSS),respectively.The levels of IL-6,IL-4,IL-1β,CD3+,CD4+,CD8+,CD4+/CD8+between the two groups were compared.The correlation between inflammatory cytokines,T lymphocyte subsets and depression,mania state,suicide idea in the two groups was analyzed by Pearson correlation analysis.Re-sults The scores of HAMD-24,HCL-32 and SIOSS in BD-Ⅱ group were higher than those in MDD group(t=2.20,10.00,2.71,P<0.05).There was no significant difference in level of serum IL-1β between the two groups(t=1.57,P>0.05).The levels of serum IL-6 and IL-4 in BD-Ⅱ group were higher than those in MDD group(t=8.88,3.60,P<0.05).There was no significant difference in CD4+/CD8+between the two groups(t=1.10,P>0.05).The levels of CD3+,CD4+and CD8+in BD-Ⅱ group were higher than those in MDD group(t=2.83,2.64,2.68,P<0.05).In BD-Ⅱ patients,the serum levels of IL-6,IL-4,CD3+,CD4+,CD8+were positively correlated with HAMD-24,HCL-32,and SIOSS scales(P<0.05).The serum levels of IL-6,IL-4,CD3+,CD4+,CD8+in MDD patients were positively correlated with HAMD-24,HCL-32,and SIOSS scales(P<0.05).Conclusion Compared with MDD patients,levels of serum IL-6,IL-4,CD3+,CD4+and CD8+are higher in BD-Ⅱ patients.The above indexes are positively correlated with scores of depression,mania state and suicide idea.
基金项目
浙江省基础公益研究计划项目(LGF22H090050)
维普
万方数据