Objective To explore the application effect of flipped classroom combined with medical simulation in training the comprehensive clinical emergency abilities of new pediatric nurses.Methods Newly recruited nurses from the 2020 and 2021 grade were selected,with 52 nurses from the 2020 grade as the control group and 39 nurses from the 2021 grade as the experimental group.The control group received traditional teaching,while the experimental group used flipped classroom combined with medical simulation.At the end of the course,the scores of team communication and co-operation ability and CPR self-confidence between the two groups of new nurses were compared,and the overall teaching was evaluated by the teaching evaluation questionnaire.Results The ability of team communication and cooperation and the confidence of cardiopulmonary resuscitation of new nurses in the experimental group were significantly higher than those in the control group,and the differences were statistically significant(t=-2.15,-2.01,P<0.05).The evaluation score of the training program of new nurses in the experimental group was significantly higher than that in the control group,and the difference was statistically significant(t=-5.98,P<0.05).The scores of simulation design scale,simula-tion teaching practice scale and learning satisfaction and confidence scale for new nurses in the experimental group were 80(80,94),64(64,74)and 52(51,59),respectively.Conclusion The training program of flipped classroom combined with medical simulation effectively enhances the comprehensive clinical emergency abilities of pediatric nurses.Future ad-justments to the training program should be made based on participants'performance to continually optimize outcomes.