摘要
目的 探讨不同频率重复经颅磁刺激(rTMS)治疗精神分裂症患者疗效及对事件相关电位P3波(P300)的影响.方法 选取112 例精神分裂症患者,按照随机数字表法分为三组:5 Hz组(n=38)、10 Hz组(n=37)、15 Hz组(n=37).所有患者均维持原用抗精神病药物治疗剂量不变,在此基础上对应给予频率为5 Hz、10 Hz、15 Hz的rTMS治疗,持续治疗5 周.治疗后,比较三组患者的疗效、P300潜伏期和波幅、认知功能以及不良反应的差异.结果 治疗后,10 Hz组患者的治疗有效率均高于5Hz组和15 Hz组,P300水平中的波幅和认知功能评分均高于5Hz组和15 Hz组,差异均有统计学意义(χ2分别=4.82、6.19,t分别=3.57、9.01、2.07、5.46,P均＜0.05),且10 Hz组患者的副反应量表(TESS)总分均低于5Hz组和15 Hz组,差异均有统计学意义(t分别=5.50、6.45,P均＜0.05).5Hz组和15 Hz组间的治疗有效率、P300波幅、认知功能评分和TESS总分比较,差异均无统计学意义(χ2=0.11,t分别=1.78、1.93、1.38,P均＞0.05).结论 与5 Hz、15 Hz的rTMs相比,频率为10 Hz的rTMS疗效更好,能显著改善精神分裂症患者主要症状、P300水平、认知功能,且安全性更高.
Abstract
Objective To explore the effect of different frequencies of repetitive transcranial magnetic stimulation(rT-MS)in patients with schizophrenia and its influences on event-related potential P3 wave(P300).Methods A total of 112 patients with schizophrenia were enrolled and divided into 5 Hz group(n=38),10 Hz group(n=37)and 15 Hz group(n=37)according to random number table method.On basis of original dose of antipsychotics,the three groups were treated with different frequencies of rTMS(5 Hz,10 Hz,15 Hz)for 5 weeks.After treatment,The difference of effi-cacy,P300 level,cognitive function and adverse reactions among the three groups was compared.Results After treat-ment,the treatment effective rate of patients in the 10 Hz group was higher than that in the 5 Hz and 15 Hz groups,am-plitude of P300 and score of cognitive function were higher than those in the 5 Hz and 15 Hz groups,with statistical sig-nificance(χ2=4.82,6.19,t=3.57,9.01,2.07,5.46,P＜0.05).The total scores of TESS in the 10 Hz group were lower than those in the 5 Hz and 15 Hz groups,with statistical significance(t=5.50,6.45,P＜0.05).There were no significant differ-ences in treatment response rate,amplitude of P300,cognitive function score and TESS total score between the 5 Hz and 15 Hz groups(χ2=0.11,t=1.78,1.93,1.38,P＞0.05).Conclusion Compared with 5 Hz and 15 Hz rTMS,10 Hz rTMS has better curative effect,which can significantly improve main symptoms,P300 level and cognitive function in schizo-phrenia patients,with higher safety.
维普
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