Objective To explore the practical effect of using outcomes-based education(OBE)to cultivate innova-tive talents based on multi-disciplinary collaboration(MDT)model.Methods A total of 46 students who received stan-dardized training in our hospital from 2022 to 2023 were selected and divided into experimental group and control group according to random number table method,with 23 students in each group.The experimental group adopted the teaching mode of cultivating compound innovative talents with OBE based on MDT model,while the control group adopted the tra-ditional teaching mode.After the training,the results of the final examination,the satisfaction of teaching effect and the evaluation of individual comprehensive quality were compared between the two groups.Results The test scores,teaching satisfaction,self-rating comprehensive ability and total scores of the experimental group were higher than those of the control group,and the differences were statistically significant(t=-5.50,-9.18,-7.22,-12.65,P<0.05).Conclusion Compared with the traditional teaching method,the OBE teaching mode based on MDT model can more effectively culti-vate the compound talents with comprehensive ability and innovative thinking.