全科医学临床与教育2024，Vol.22Issue(12) ：1067-1070.DOI:10.13558/j.cnki.issn1672-3686.2024.012.004

经颅直流电刺激治疗双相情感障碍抑郁发作的效果及对抑郁症状改善情况、认知功能及生活质量的影响

Effect of transcranial direct current stimulation on depressive episode in bipolar disorder and its impact on the improvement of depressive symptoms,cognitive function,and quality of life

何洁智 栾泓霖 金爱敏 叶嘉恩
全科医学临床与教育2024，Vol.22Issue(12) ：1067-1070.DOI:10.13558/j.cnki.issn1672-3686.2024.012.004
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经颅直流电刺激治疗双相情感障碍抑郁发作的效果及对抑郁症状改善情况、认知功能及生活质量的影响

Effect of transcranial direct current stimulation on depressive episode in bipolar disorder and its impact on the improvement of depressive symptoms,cognitive function,and quality of life

何洁智 1栾泓霖 2金爱敏 3叶嘉恩4
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作者信息

  • 1. 325000 浙江温州,温州市第七人民医院老年精神科
  • 2. 325000 浙江温州,温州市第七人民医院物理治疗室
  • 3. 325000 浙江温州,温州市第七人民医院精神综合三病区
  • 4. 325000 浙江温州,温州市第七人民医院优抚二病区
  • 折叠

摘要

目的 探讨经颅直流电刺激(tDCS)治疗双相情感障碍抑郁发作的效果及对抑郁症状改善情况、认知功能及生活质量的影响.方法 选取80 例双相情感障碍抑郁发作患者作为研究对象,采用随机数字表法将患者分为对照组和观察组,各40 例,对照组给予常规药物+伪刺激治疗,观察组给予常规药物+tDCS治疗,分别比较两组临床疗效、抑郁状况、认知功能、生活质量.结果 观察组临床总有效率高于对照组(χ2=4.11,P＜0.05).治疗后,观察组汉密尔顿抑郁量表-17(HAMD-17)、匹兹堡睡眠质量指数(PSQI)评分较对照组低(t分别=3.43、3.16,P均＜0.05).治疗后,观察组完成分类数、正确应答数评分较对照组高,错误应答数及持续错误数评分较对照组低(t分别=5.25、5.35、-4.62、-3.40,P均＜0.05).治疗后,观察组生活质量综合评定问卷-74(GQOLI-74)各维度评分较对照组高(t分别=5.11、6.72、8.62、3.32,P均＜0.05).结论 tDCS可有效改善双相情感障碍抑郁发作患者抑郁程度、认知功能及生活质量,临床疗效较佳.

Abstract

Objective To explore the effect of transcranial direct current stimulation(tDCS)on depressive episode of bipolar disorder and its impact on the improvement of depressive symptoms,cognitive function,and quality of life.Meth-ods Totally 80 patients with bipolar disorder and depressive episodes were selected as the study subjects.The patients were randomly divided into a control group and an observation group,with 40 patients in each group.The control group re-ceived conventional medicine combined with pseudo stimulus treatment,while the observation group received convention-al medicine combined with tDCS treatment.The clinical efficacy,depression status,cognitive function,and quality of life of the two groups were compared.Results The total clinical effective rate of the observation group was higher than that of the control group(χ2=4.11,P＜0.05).After treatment,the Hamilton depression scale(HAMD-17)and Pittsburgh sleep quality index(PSQI)scores in the observation group were lower than those in the control group(t=3.43,3.16,P＜0.05).After treatment,the observation group had higher scores for classification completion and correct answer scores than the control group,while the scores for incorrect answer scores and continuous error scores were lower than the con-trol group(t=5.25,5.35,-4.62,-3.40,P＜0.05).After treatment,the generic quality of life inventory-74(GQOLI-74)score in the observation group was higher than that in the control group(t=5.11,6.72,8.62,3.32,P＜0.05).Conclu-sion tDCS can effectively improve the degree of depression,cognitive function,and quality of life in patients with bipo-lar disorder and depressive episode,with better clinical efficacy.

关键词

经颅直流电刺激/双相情感障碍/抑郁发作/认知功能/生活质量

Key words

transcranial direct current stimula-tion/bipolar disorder/depressive episode/cognitive function/quality of life

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出版年

2024
全科医学临床与教育
浙江大学

全科医学临床与教育

影响因子：0.63
ISSN：1672-3686
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