摘要
目的 分析血清β2微球蛋白(β2-MG)、红细胞沉降率(ESR)水平及外周血血细胞参数与系统性红斑狼疮(SLE)活动性的相关性.方法 选取155 例SLE患者为研究对象,根据是否有活动性分为活动组(n=104)和无活动组(n=51).采用系统性红斑狼疮疾病活动指数(SLEDAI)评分评估SLE活动性,并分为轻度、中度、重度活动组.比较活动组及无活动组两组间血清β2-MG、ESR水平、外周血血细胞参数;绘制ROC曲线评估血清β2-MG、ESR水平及外周血血细胞参数对SLE患者活动性的预测价值;并分析血清β2-MG、ESR水平、外周血血细胞参数与SLE活动性的相关性.结果 与无活动组的SLE患者相比,活动组β2-MG、ESR、红细胞分布宽度(RDW)、中性粒细胞淋巴细胞比值(NLR)、C反应蛋白(CRP)、平均血小板体积(MPV)水平均较高(t分别=-10.99、-8.47、-8.64、-13.23、-17.60、-12.47,P均＜0.05),血红蛋白(HGB)、血小板计数(PLT)水平均较低(t分别=3.89、4.39,P均＜0.05).β2-MG、ESR、HGB、PLT、RDW、NLR、MPV、CRP对SLE患者活动性的预测价值的AUC值分别为0.91、0.80、0.64、0.72、0.81、0.93、0.93、0.91.β2-MG、ESR、RDW、NLR、CRP、MPV水平随SLE患者活动性程度增加而增加(F分别=1436.98、324.46、81.25、57.25、102.07、24.24,P均＜0.05);HGB、PLT水平随SLE患者活动性程度增加而降低(F分别=19.61、7.72,P均＜0.05).Spearman相关分析显示,SLE患者活动性与β2-MG、ESR、RDW、NLR、CRP、MPV水平呈正相关(rs分别=0.86、0.78、0.73、0.84、0.76、0.82,P均＜0.05),与HGB、PLT水平呈负相关(rs分别=-0.42、-0.39,P均＜0.05).结论 SLE患者SLEDAI评分与β2-MG、ESR、RDW、NLR、CRP、MPV水平呈正相关,与HGB、PLT水平呈负相关.血清β2-MG、ESR水平及外周血血细胞参数对SLE患者活动性均有较好的预测价值,可为SLE患者的评估提供依据.
Abstract
Objective To analyze the correlation of serum β2-MG,ESR levels and peripheral blood haematological parameters with systemic lupus erythematosus(SLE)activity.Methods A total of 155 patients with SLE were selected and divided into an active group(n=104)and an inactive group(n=51)according to whether they were active or not.SLE activity was assessed by the systemic lupus erythematosus disease activity index(SLEDAI)score and categorized in-to mild-activity,moderate-activity and severe-activity groups.The serum β2-MG,ESR levels,and peripheral blood hae-matocrit parameters between the active and inactive groups were compared.The ROC curve was used to assess the predic-tive value of serum β2-MG,ESR levels and peripheral blood haematocrit parameters on the activity of SLE patients.The correlation of serum β2-MG,ESR levels,peripheral blood haematocrit parameters and SLE activity.Results Compared with SLE patients in the inactive group,the active group had higher levels of β2-MG,ESR,RDW,NLR,CRP,and MPV(t=-10.99,-8.47,-8.64,-13.23,-17.60,-12.47,P＜0.05),and lower levels of HGB and PLT,with statistically signifi-cant differences(t=3.89,4.39,P＜0.05).The AUC values for the predictive value of β2-MG,ESR,HGB,PLT,RDW,NLR,MPV,and CRP for activity in SLE patients were 0.91,0.80,0.64,0.72,0.81,0.93,0.93,and 0.91,respectively.The levels of β2-MG,ESR,RDW,NLR,CRP,and MPV increased with increasing ac-tivity in SLE patients,and the differences were significant between different activities(F=1436.98,324.46,81.25,57.25,102.07,24.24,P＜0.05).The levels of HGB and PLT decreased with increasing activity in SLE patients,and the differ-ences were significant between different activities(F=19.61,7.72,P＜0.05).Spearman correlation analysis showed that the activity level of SLE patients was positively correlated with the levels of β2-MG,ESR,RDW,NLR,CRP,and MPV(rs=0.86,0.78,0.73,0.84,0.76,0.82,P＜0.05),and negatively correlated with the levels of HGB and PLT(rs=-0.42,-0.39,P＜0.05).Conclusion The SLEDAI score of SLE patients was positively correlated with the levels of β2-MG,ESR,RDW,NLR,CRP,and MPV,and negatively correlated with the levels of HGB and PLT.Serum β2-MG,ESR levels and peripheral blood haematocrit parameters have good predictive value for the activity of SLE patients,which can pro-vide a basis for the assessment of SLE patients.
维普
万方数据