Effects of combining the Huayu Xuzhe decoction with the MIPO technique on TNF-α,β-EP,IL-6 and bone metabolic indexes in closed middle and lower tibial fractures(Qi Stagnation and Blood Stasis Syndrome)
Effects of combining the Huayu Xuzhe decoction with the MIPO technique on TNF-α,β-EP,IL-6 and bone metabolic indexes in closed middle and lower tibial fractures(Qi Stagnation and Blood Stasis Syndrome)
Objective To explore the application value of Huayu Xuzhe decoction combined with MIPO technology in the treatment of closed middle and lower tibial fractures(Qi stagnation and blood stasis syndrome).Methods A total of 128 cases of closed middle and lower tibial fractures(Qi stagnation and blood stasis syndrome)were selected and divid-ed into two groups according to the random number table method,64 cases in each groups.The control group was treated with MIPO technology,and the observation group was treated with Huayu Xuzhe decoction combined with MIPD technol-ogy,and the efficacy was compared after 4 weeks of treatment.Results After treatment,the serum levels of β-endor-phins(β-EP)and osteoprotegerin(OPG)in the observation group were higher than those in the control group,while the levels of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),5-hydroxytryptamine(5-HT)and β-collagen special sequence(β-CTX)in the observation group were lower than those in the control group,and the differences were statisti-cally significant(t=-7.69,-9.12,11.09,20.06,10.64,18.49,P＜0.05).After treatment,the total symptom score,fracture healing time and time off bed after surgery in the observation group were lower than those in the control group,while the ankle-hindfoot score in the observation group was higher than that in the control group,and the differences were statisti-cally significant(t=8.25,9.21,6.84,-20.83,P＜0.05).The total excellent rate of ankle joint function in the observation group was 98.44%,which was higher than that of the control group(85.94%),and the difference was statistically signifi-cant(χ2=6.94,P＜0.05).Conclusion For patients with closed middle and lower tibial fractures(Qi stagnation and blood stasis syndrome),the Huayu Xuzhe decoction combined with MIPO technology can help to reduce inflammation,regulate bone metabolism,promote fracture healing,and improve clinical efficacy.
关键词
化瘀续折方/微创接骨板内固定技术/闭合性胫骨中下段骨折/气滞血瘀证
Key words
Huayu Xuzhe decoction/minimally invasive percutaneous osteosynthesis/closed middle and lower tib-ial bone fracture/Qi stagnation and blood stasis syndrome
维普
万方数据