Objective To explore the influence of OSCE guided scene practice teaching based on CDIO model on the training effect of junior nurses in endoscopy center.Methods A total of 35 junior nurses in the endoscopy center were se-lected to carry out a 4-month OSCE guided scene practice training based on CDIO mode.The results of theoretical and oper-ational assessment of nurses with low years of experience,the degree of recognition of clinical performance of trainees and the evaluation of the trainees'OSCE training process and effect were compared.Results After training,the theoretical and operational assessment scores of junior nurses were significantly improved compared with those before training(t=26.35,22.33,P<0.05).The recognition degree of supervisors to the clinical performance of junior nurses was significantly higher than that before training(t=4.93,4.65,3.56,3.10,3.96,P<0.05).The process evaluation and effect evaluation of junior nurs-es to OSCE were high.Conclusion The OSCE guided scene practice teaching design based on CDIO mode is scientific and reasonable,which is helpful to improve the clinical comprehensive ability of junior nurses in endoscopy center.