摘要
目的:研究奥司他韦、帕拉米韦对病毒性肺炎患儿血清生长停滞特异性基因产物6(GAS6)、肺表面活性蛋白D(SPD)、免疫球蛋白水平影响的对比.方法:以2021年3月-2022年4月我院收集的126例病毒性肺炎患儿为研究对象,以数字表法患儿分为常规组和实验组,每组各63例.常规组采用奥司他韦治疗,实验组采用帕拉米韦治疗.比较两组临床疗效、临床症状消失时间、治疗前后血气分析指标[氧分压(PaO2)、二氧化碳分压(PaCO2)]、血清免疫球蛋白水平[免疫球蛋白A(IgA)、免疫球蛋白M(IgM)、免疫球蛋白G(IgG)]、血清白介素8(IL-8)、肿瘤坏死因子-α(TNF-α)、GAS6和SPD水平.结果:实验组临床总有效率98.41％(62/63)高于常规组87.30％(55/62)(P＜0.05);实验组临床症状消失时间短于常规组(P＜0.05);治疗1个疗程后实验组PaO2高于对照组,PaCO2低于对照组(P＜0.05);治疗1个疗程后实验组血清IgA、IgM、IgG水平高于常规组(P＜0.05);治疗1个疗程后实验组血清IL-8、TNF-α、GAS6、SPD水平低于常规组(P＜0.05).结论:与奥司他韦相比,帕拉米韦治疗病毒性肺炎患儿效果更为显著,可有效缓解临床症状,改善血气分析指标及免疫球蛋白水平,促进病情恢复.
Abstract
Objective:To compare the effects of oseltamivir and peramivir on serum growth arrest specific gene product 6(GAS6),pulmonary surfactant protein D(SPD)and immunoglobulin levels in children with viral pneumonia.Methods:A total of 126 children with viral pneumonia collected in our hospital from March 2021 to April 2022 were selected as the research objects,and the children were divided into a routine group and an experimental group by numerical table method,with 63 cases in each group.The routine group was treated with oseltamivir,and the experimental group was treated with peramivir.The clinical efficacy,disappearance time of clinical symptoms,blood gas analysis indexes[partial pressure of oxygen(PaO2),partial pressure of carbon dioxide(PaCO2)],serum immunoglobulin levels[immunoglobulin A(IgA),immunoglobulin M]before and after treatment were compared between the two groups(IgM),immunoglobulin G(IgG)],serum interleukin-8(IL-8),tumor necrosis factor-α(TNF-α),GAS6,SPD levels.Results:The clinical total effective rate of the experimental group was 98.41％(62/63)higher than that of the routine group 87.30％(55/62)(P＜0.05);The clinical symptoms disappeared time of the experimental group was shorter than that of the routine group(P＜0.05);After one course of treatment,PaO2 in the experimental group was higher than that in the control group,and PaCO2 was lower than that in the control group(P＜0.05);After one course of treatment,the levels of serum IgA,IgM and IgG in the experimental group were higher than those in the conventional group(P＜0.05);After one course of treatment,the serum levels of IL-8,TNF-α,GAS6 and SPD in the experimental group were lower than those in the conventional group(P＜0.05).Conclusion:Compared with oseltamivir,peramivir is more effective in the treatment of children with viral pneumonia,can effectively relieve clinical symptoms,improve blood gas analysis indicators and immune globulin levels,and promote disease recovery.
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