Objective:To investigate the relationship between serum vaspin level and severity,prognosis and inflammatory factors in patients with acute cerebral infarction(ACI).Methods:105 patients with ACI were divided into 3 groups:mild stroke group,moderate stroke group and severe stroke group according to the degree of stroke.Thirty-four healthy persons were selected as control group.The serum levels of vaspin,IL-6,HSCRP and other biochemical IL-6 were measured by Elisa.Results:The levels of vaspin in ACI Group were significantly lower than those in healthy control group,and the levels of IL-6 and HSCRP in ACI Group were significantly higher than those in healthy control group(P＜0.01),the levels of Vaspin in moderate stroke group were lower than those in mild stroke group,and the levels of IL-6 and HSCRP in moderate stroke group were higher than those in mild stroke group(P＜0.01),in ACI Group,serum vaspin was negatively correlated with FBG,FINS,HOMA-IR,TG,LDL-C,IL-6,HSCRP(R=-0.409,-0.341,-0.305,-0.286,-0.357,-0.415,-0.388,P＜0.05),and positively correlated with BMI and HDL-C,the R values were(0.459,0.375,P＜0.05),and had no correlation with age,BSP and HSP(P＞0.05).Conclusion:The serum level of vaspin is decreased in patients with ACI,and it is correlated with the degree of stroke,the prognosis,the expression of IL-6 and HSCRP.Vaspin can be used to judge the severity of the disease and evaluate the prognosis.
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