Objective:To explore the clinical value of combined detection of neutrophil to lymphocyte ratio(NLR),platelet to lymphocyte ratio(PLR),lymphocyte to Monocyte ratio(LMR),mean platelet volume to platelet count ratio(MRP)and cytomegalovirus specific antibody(CMV IgM)in the diagnosis of cytomegalovirus(CMV)infection in infants.Methods:150 infants and young children with CMV infection admitted to our hospital from January 2020 to December 2022 were selected as the observation group,and 60 healthy infants and young children in the same period were selected as the control group.All infants and young children were collected for blood routine testing to obtain NLR,PLR,LMR,MPR,and serum CMV-IgM.Compare the differences in NLR,PLR,LMR,MPR,and CMV-IgM levels between the two groups;Draw Receiver operating characteristic and analyze the clinical value of combined detection of NLR,PLR,LMR,MPR and CMV IgM to identify infant CMV infection.The serum levels of NLR,PLR,and LMR in the observation group were(0.29±0.05),(45.41±4.12)and(7.85±1.24),which were lower than those in the control group(0.55±0.11),(69.87±6.12)and(5.14±1.02).The levels of MPR and CMV-IgM were(0.41±0.12),(23.65±2.42)AU/mL,which were higher than those in the control group(0.22±0.05),(10.22±1.23)AU/mL,and the difference was statistically significant(P＜0.05);The Receiver operating characteristic showed that the area under the curve of serum NLR,PLR,LMR,MPR,CMV IgM and combined detection for diagnosis of infant CMV infection were 0.802,0.763,0.786,0.799,0.850 and 0.950,respectively.Conclusion:The combined detection of NLR,PLR,LMR,MPR and CMV-IgM has high value in the diagnosis of CMV in infants and young children.It can improve diagnostic sensitivity and specificity,reduce the risk of missed diagnosis and misdiagnosis,facilitate early treatment work,and ensure the healthy growth of children.
Cytomegalovirus infection in infants and young childrenNeutrophil to lymphocyte ratioPlatelet to lymphocyte ratioCytomegalovirus specific antibody
维普
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