医学检验与临床2024，Vol.35Issue(1) ：46-50.DOI:10.3969/j.issn.1673-5013.2024.01.011

Rh系统抗-D与抗-E抗体共同致新生儿溶血病的研究分析

The research and analysis of hemolytic disease of new born causing by anti-D with anti-E in Rh system

吴晓春 姜坤 于晓梅 孙福廷
医学检验与临床2024，Vol.35Issue(1) ：46-50.DOI:10.3969/j.issn.1673-5013.2024.01.011
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Rh系统抗-D与抗-E抗体共同致新生儿溶血病的研究分析

The research and analysis of hemolytic disease of new born causing by anti-D with anti-E in Rh system

吴晓春 1姜坤 1于晓梅 1孙福廷1
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作者信息

  • 1. 潍坊市人民医院输血科,山东潍坊 261041
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摘要

目的:研究1例Rh系统2种不规则抗体(抗-D、抗-E)同时存在导致新生儿溶血病.方法:通过临床资料提供,对产妇进行血型分析,不规则抗体筛查及抗体特异性鉴定,抗体效价分析;对新生儿进行直接抗人球蛋白试验、游离试验、放散试验及抗体特异性分析.结果:产妇不规则抗体阳性,抗体为Rh系统抗-D与抗-E,IgG抗-D效价为512,IgG抗-E效价为2;新生儿直接抗人球蛋白试验阳性、放散试验检出抗-D和抗-E抗体,游离试验检出抗-D抗体.结论:经新生儿三项实验诊断新生儿溶血病成立,积极给予对症治疗,患儿康复出院.

Abstract

Objective:To investigated one case of hemolytic disease of the new born caused by simultaneous of two irregular antibodies(anti-D and anti-E)in Rh system.Methods:Provided by clinical data,After blood group identification and irregular antibody screening of pregnant woman,determining titer of antibody by means of immunoserology;Direct antiglobulin test,antibody release test,free antibody test and further antibody identification conducting for the new born.Results:The irregular antibody is positive combining anti-D with anti-E in Rh system,the IgG titer of antibody was 512 and 2;Direct antiglobulin test is positive,antibody release test appearing anti-D and anti-E,anti-D presented in free antibody test.Conclusion:The diagnosis of hemolytic disease of new born was established and the child recovery discharged from hospital smoothly gived by symptomatic treatment actively.

关键词

新生儿溶血病/RhD阴性/抗-D/抗-E

Key words

Hemolytic disease of new born/RhD negative/Anti-D/Anti-E

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出版年

2024
医学检验与临床
山东省千佛山医院

医学检验与临床

影响因子：0.294
ISSN：1673-5013
参考文献量19
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