老年维持性血液透析患者外周血NLR、PLR、HGB水平与钙磷代谢异常和全因病死率的关系研究
Relationship between peripheral blood NLR,PLR,HGB and abnormal calcium-phosphorus metabolism,all-cause mortality in elderly patients undergoing maintenance hemodialysis
李君华1
作者信息
- 1. 单县中医医院检验科,山东菏泽 274300
- 折叠
摘要
目的:探讨老年维持性血液透析(MHD)患者外周血中性粒细胞与淋巴细胞比率(NLR)、血小板/淋巴细胞比值(PLR)、血红蛋白(HGB)水平与钙磷代谢异常和全因病死率的关系.方法:回顾性分析我院2021年5月-2022年5月的108例老年MHD患者临床资料,检测外周血NLR、PLR、HGB水平、钙磷代谢情况.记录生存情况,根据患者的存活情况分为存活组和死亡组,采用Pearson相关性分析外周血NLR、PLR、HGB水平与钙磷代谢的相关性,采用COX回归分析老年MHD患者全因死亡的影响因素.结果:108例老年MHD患者死亡35例,存活73例,存活组和死亡组的总生存率分别为90.42％、76.15％,两组间生存率有统计学意义(Log-rank x2=4.264,P=0.039),存活组透析时间低于死亡组(P＜0.05);存活组NLR、PLR值均低于死亡组(P＜0.05),两组HGB水平无明显差异(P＞0.05);存活组血钙值高于死亡组,血磷、钙磷乘积水平均低于死亡组(P＜0.05);Pearson相关性分析显示,外周血NLR、PLR与血钙呈负相关,与血磷、钙磷乘积呈正相关,外周血HGB水平与血钙呈正相关,与血磷、钙磷乘积呈负相关(P＜0.05);COX回归分析显示NLR、PLR、血钙、血磷、钙磷乘积为老年MHD患者全因死亡的影响因素(P＜0.05).结论:外周血NLR、PLR及钙磷代谢水平与老年MHD患者预后密切相关,是老年MHD患者全因死亡的影响因素.
Abstract
Objective:To explore the relationship between peripheral blood neutrophil to lymphocyte ratio(NLR),platelet/lymphocyte ratio(PLR),hemoglobin(HGB)and abnormal calcium-phosphorus metabolism,all-cause mortality in elderly patients undergoing maintenance hemodialysis(MHD).Methods:A retrospective analysis was performed on the clinical data of 108 elderly patients undergoing MHD in the hospital between May 2021 and May 2022.The levels of peripheral blood NLR,PLR and HGB,and calcium-phosphorus metabolism were detected.According to survival situations,patients were divided into survival group and death group.The correlation between peripheral blood NLR,PLR,HGB levels and calcium-phosphorus metabolism was analyzed by Pearson correlation analysis,and the influencing factors of all-cause death in elderly MHD patients were analyzed by COX regression analysis.Results:In the 108 elderly MHD patients,there were 35 death cases and 73 survival cases.The overall survival rates in survival group and death group were 90.42％and 76.15％,and the difference between the two groups was statistically significant(Log-rank x2=4.264,P=0.039).The dialysis time in survival group was shorter than that in death group(P＜0.05).NLR and PLR in survival group were lower than those in death group(P＜0.05),but there was no significant difference in HGB level between the two groups(P＞0.05).The level of blood calcium in survival group was higher than that in death group,while levels of blood phosphorus and calcium-phosphorus product were lower than those in death group(P＜0.05).Pearson correlation analysis showed that peripheral blood NLR and PLR were negatively correlated with blood calcium,while positively correlated with blood phosphorus and calcium-phosphorus product,and peripheral blood HGB was positively correlated with blood calcium,while negatively correlated with blood phosphorus and calcium-phosphorus product(P＜0.05).COX regression analysis showed that NLR,PLR,blood calcium,blood phosphorus and calcium-phosphorus product were influencing factors of all-cause death in elderly MHD patients(P＜0.05).Conclusion:Peripheral blood NLR,PLR and calcium-phosphorus metabolism are closely related to prognosis of elderly MHD patients,which are influential factors of all-cause death.
关键词
老年维持性血液透析/中性粒细胞与淋巴细胞比率/血小板/淋巴细胞比值/血红蛋白/全因病死率Key words
Elderly maintenance hemodialysis/Neutrophil to lymphocyte ratio/Platelet/lymphocyte ratio/Hemoglobin/All-cause mortality引用本文复制引用
出版年
2024
NETL
NSTL
维普
万方数据