临沂地区35124例血清学产前筛查结果分析
Analysis of serological prenatal screening results of 35124 cases in Linyi area
冯桐 1李华锋1
作者信息
- 1. 临沂市妇幼保健院医学遗传科,山东临沂 276000
- 折叠
摘要
目的:回顾分析2019年-2022年临沂市妇幼保健院35124例血清学产前筛查结果.方法:应用Auto DELFIA 1235时间分辨免疫荧光分析仪对28557例孕妇进行血清学早中孕整合模式筛查,6567例孕妇进行中孕三联筛查,再结合孕妇的孕周、年龄、体重等信息进行计算,得出孕妇怀有出生缺陷患儿的风险值.对存在风险的孕妇行产前诊断并随访其妊娠结局.结论:共筛出21三体高风险1521例(4.33％),18三体高风险65例(0.19％),开放性神经管缺陷高风险237例(0.67％).经产前诊断确诊21三体综合征23例,18三体综合征7例,开放性神经管缺陷17例.早中孕整合筛查比中孕三联筛查的阳性预测值高,不同孕周和不同年龄的高风险率不同.
Abstract
Objective:To retrospectively analyze the serological prenatal screening results of 35124 cases in Linyi Women and Children's Hospital from 2019 to 2022.Methods:Serological screening was performed on 28557 pregnant women with integrated pattern of early and middle pregnancy and on 6567 pregnant women with triple screening for middle pregnancyby using Auto DELFIA 1235 time-resolved immunofluorescence analyzer.Then combined with pregnant women's gestational age,age,weight and other information to calculate the risk value of pregnant women with birth defects.Prenatal diagnosis and follow-up of pregnancy outcomes were performed for at-risk pregnant women.Conclusion:A total of 1521 patients(4.33％)were at high risk of trisomy 21,65(0.19％)were at high risk of trisomy 18 and 237(0.67％)were at high risk of open neural tube defects.Prenatal diagnosis confirmed 23 cases of trisomy 21 syndrome,7 cases of trisomy 18 syndrome,and 17 cases of open neural tube defects.The positive predictive value of integrated screening in early and middle pregnancy was higher than that of triplets in middle pregnancy,and the risk rate was different in different gestational weeks and different ages.
关键词
血清学产前筛查/高风险/出生缺陷Key words
Serological prenatal screening/High risk/Birth defect引用本文复制引用
出版年
2024
NETL
NSTL
维普
万方数据