摘要
目的:探讨阿司匹林对慢性萎缩性胃炎患者血清学检查的影响.方法:选择2021年6月-2022年10月东昌府人民医院医院收治的265例慢性萎缩性胃炎患者,其中研究组158例(服用阿司匹林肠溶片100 mg/天,1年),对照组107例,收集分析两组入组前、入组半年和入组一年时血清PG、PGR和胃泌素17变化,分析服用阿司匹林肠溶片对慢性萎缩性胃炎患者血清学检查的影响.结果:研究组服用阿司匹林半年后PGⅠ、PG Ⅱ水平均较用药前增高,差异有统计学意义(t=2.378、2.561,P＜0.05),较对照组增高,差异有统计学意义(t=2.739、2.338,P＜0.05);但PGR与胃泌素17水平较用药前及同时段对照组比较差异无统计学意义(P＞0.05);研究组用药一年后较用药前,PGⅠ、PG Ⅱ水平增高,PGR与胃泌素17降低,差异均有统计学意义(t=4.376、5.782、3.536,Z=6.029,P＜0.05);用药一年后较对照组PGⅠ、PG Ⅱ水平增高,PGR与胃泌素17降低,差异均有统计学意义(t=3.918、5.074、3.186,Z=6.749,P＜0.05).用药一年后,胃黏膜异型增生、肠上皮化生、腺体萎缩程度均较治疗前降低,差异均有统计学意义(t=1.682、3.252、3.469,P＜0.05).结论:服用阿司匹林肠溶片可改善慢性萎缩性胃炎患者胃黏膜的分泌功能,且该作用可能存在用药时间节点.
Abstract
Objective:Exploring the impact of aspirin on serological examinations in patients with chronic atrophic gastritis.Methods:From June 2021 to October 2022,a total of 265 patients with chronic atrophic gastritis were admitted to the hospital.Among them,there were 158 cases in the study group(taking aspirin enteric-coated tablets 100 mg/day for a total of 1 year)and 107 cases in the control group.Serum levels of PG,PGR,and gastrin-17 were collected and analyzed before enrollment,at six months,and at one year after enrollment in both groups.The study aimed to analyze the impact of taking aspirin enteric-coated tablets on serological examinations in patients with chronic atrophic gastritis.Results:In the study group,the levels of PG Ⅰ and PG Ⅱ increased significantly after six months of taking aspirin,with statistically significant differences(t=2.378,2.561,P＜0.05)compared to before medication.The levels were also higher compared to the control group,with statistically significant differences(t=2.739,2.338,P＜0.05).However,there were no statistically significant differences in PGR and gastrin-17 levels compared to before medication or compared to the control group during the same period(P＞0.05).In the study group,after one year of medication,there were significant increases in the levels of PG Ⅰ and PG Ⅱ,and significant decreases in PGR and gastrin-17 levels compared to before medication,with statistically significant differences(t=4.376,5.782,3.536,Z=6.029,P＜0.05).Additionally,after one year of medication,the levels of PG Ⅰ and PG Ⅱ were higher,and PGR and gastrin-17 levels were lower compared to the control group,with statistically significant differences(t=3.918,5.074,3.186,Z=6.749,P＜0.05).After one year of treatment,the degrees of gastric mucosal dysplasia,intestinal epithelial metaplasia and gland atrophy were all lower than those before treatment,and the differences were statistically significant(t=1.682、3.252、3.469,P＜0.05).Conclusion:Taking aspirin enteric-coated tablets can improve the secretion function of gastric mucosa in patients with chronic atrophic gastritis,and this effect may be influenced by the duration of medication.
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