Objective:To explore the distribution of pathogens bacteria and expressions of inflammatory factors in 80 stroke patients infected with pneumonia.Methods:A total of 80 patients with ischemic stroke were admitted to Zaozhuang Central Hospital of Shandong Guoxin Yiyang Group were enrolled as stroke group between February 2020 and February 2021.According to presence or absence of pulmonary infection,they were divided into infection group(n=43)and non-infection group(n=37).A total of 80 healthy controls during the same period were enrolled as control group.The distribution of pathogens in infection group was analyzed.The levels of serum procalcitonin(PCT),hypersensitive C-reactive protein(hs-CRP)and interleukin(IL)-8 in different groups were compared,and their relationship with disease severity was analyzed by Spearman correlation analysis.After 1 year of follow-up,the prognosis of patients was observed,and serological indexes in patients with different prognosis were compared.Results:There were 68 strains of pathogens in infection group,including Gram-negative bacteria(60.29％,mainly on Pseudomonas aeruginosa,Gram-positive bacteria(35.30％,mainly on Staphylococcus aureus)and fungi(4.41％,mainly on Candida albicans).The levels of serum PCT,hs-CRP and IL-8 were the highest in infection group,followed by non-infection group and control group(P＜0.05).Spearman correlation analysis showed that levels of serum PCT,hs-CRP and IL-8 were positively correlated with disease severity(r=0.574,0.437,0.517,P＜0.05).After 1 year of follow-up,mortality in infection group was significantly higher than that in non-infection group(30.23％vs 5.41％,P＜0.05).The levels of serum PCT,hs-CRP and IL-8 in the survived were significantly lower than those in the dead(P＜0.05).Conclusion:Gram-negative bacteria are the main pathogens in patients with ischemic stroke and pulmonary infection.The levels of serum PCT,hs-CRP and IL-8 are abnormally increased,which are closely related to disease severity and prognosis of patients.
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