Objective:To investigate the resistance of clinical isolates to commonly used antibiotics in a hospital in Tai'an City from 2019 to 2021,so as to guide rational drug use in clinic.Methods:Clinical isolates from the hospital from January 2019 to December 2021 were collected,and the results were interpreted according to the clinical and laboratory standards institute(CLSI)standards.WHONET5.6 and SPSS 22.0 software were used to analyze the data.Results:A total of 2129 strains were isolated,among which Gram-negative bacteria accounted for 78.25％and Gram-positive bacteria accounted for 21.75％.The top 5 isolated bacteria were Escherichia coli,Pseudomonas aeruginosa,Klebsiella pneumoniae,Acinetobacter baumannii and Staphylococcus aureus.The drug resistance rate of Escherichia coli to ampicillin was the highest(84.6％),and the drug resistance rate to tigecycline was the lowest.No tigecycline resistant strains were detected in 2019 and 2020,and the drug resistance rates of Escherichia coli to cefazolin,cefepime and aztreonam showed a downward trend.The detection rate of carbapenemase-resistant Klebsiella pneumoniae was higher than that of carbapenemase-resistant Escherichia coli(14.8％).The drug resistance rate of P.aeruginosa to aztreonam was the highest(54.1％).The resistance rate of Acinetobacter baumannii to commonly used antibiotics was more than 50％,and the resistance rate to tigecycline was the lowest(＜10％).No strains of Staphylococcus aureus resistant to linezolid and vancomycin were detected.Conclusion:The overall situation of bacterial drug resistance is relatively stable,some of them have a downward trend.We should still pay attention to the rational selection of drugs and strengthen drug resistance monitoring.
NETL
NSTL
万方数据
