Objective:To investigate the plasma concentration of olanzapine in the treatment of schizophrenia and its influencing factors,and to provide reference for clinical individualized drug use.Methods:Clinical data of in-patients with schizophrenia receiving olanzapine treatment in Shandong Mental Health Center in 2022 were collected.Chi-square test and logistic regression were used to analyze the effects of age,gender,dosage and whether the first dose on the blood concentration of patients.Results:A total of 1593 blood drug concentrations were monitored in 539 patients included in the analysis,of which 1250(78.47％)blood drug concentrations reached the standard.The rate of compliance of blood drug concentration in 19～40 and 41～59 age groups was 1.838 times(P=0.044)and 1.946 times(P=0.038),respectively,compared with that in ≤18 age group.The rate of conforming blood concentration in female patients was 0.460 times higher than that in male patients(P＜0.000).The rate of compliance of blood concentrations in patients taking doses 5～10 mg and 10～30 mg was 9.252 times(P＜0.001)and 11.117 times(P＜0.001),respectively,compared with patients taking doses ≤5 mg.Conclusion:The dose of olanzapine has a positive effect on the blood concentration reaching the standard,and there are individual differences.Olanzapine blood concentration monitoring should be performed regularly to improve the effectiveness and safety of the treatment of schizophrenia.
关键词
奥氮平/血药浓度/治疗药物监测/合理用药
Key words
Olanzapine/Blood drug concentration/Therapeutic drug monitoring/Rational drug application
维普
万方数据