Objective:To analyze the bacterial pathogen spectrum and drug resistance of elderly patients with acute biliary tract infection in a tertiary hospital.Methods:226 elderly patients with acute biliary tract infection admitted to the First Hospital of Zibo City from January 2018 to August 2023 were selected,and their bile was collected for bacterial culture identification,bacterial pathogen sensitivity testing,and resistance gene testing of ESBLs producing strains.Results:Among 226 elderly patients with acute biliary tract infection,139 patients(61.50％)were found to have bacteria,and 15 patients had mixed infections;A total of 155 bacterial strains were detected in the patients,with Escherichia coli accounting for 49.68％(77/155);Klebsiella pneumoniae accounted for 14.19％(22/155);Enterococcus faecium accounted for 13.55％(21/155);Enterococcus faecalis accounted for 4.52％(7/155).The proportion of ESBLs producing strains in Escherichia coli was 53.25％(41/71).The proportion of ESBLs producing strains in Klebsiella pneumoniae was 31.82％(7/22).The ESBLs resistance genes produced by Escherichia coli were blaCTX-1group(1,3,15),blaTEMand blaCTX-3group(9,14).The ESBLs resistance genes produced by Klebsiella pneumoniae were blaCTX-1group(1,3,15),blaSHVand blaTEM There was a difference in the positive rate of blaSHV between the two bacteria(x2=32.691,P＜0.001).Conclusion:The pathogenic bacteria in elderly patients with acute biliary tract infection in this area are mainly gram negative bacteria,and there has mixed infection of pathogenic bacteria;Escherichia coli producing ESBLs strains are common,and the ESBLs resistant genotypes ofEscherichia coli and Klebsiella pneumoniae are mainly blaCTX-1group(1,3,15).
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