Objective:To investigate the distribution and drug resistance changes of urinary culture pathogen from April 2021 to April 2023.Methods:The US BRUKER MALDI mass spectrometer was used for bacterial identification,and the PhoenixTM 100 automatic bacterial identification and drug sensitivity instrument was carried out for antimicrobial susceptibility test.The data were statistically analyzed by WHONET 5.6 software.Results:From April 2021 to April 2023,4163 patients had positive urine culture,among which females were more than males,and 65％of patients over 60 years old(2723/4163).The top 3 departments with positive rate of urine culture were urology,nephrology and intensive care.A total of 5283 strains of non-repeated pathogens were detected,among which gram-positive bacteria accounted for 19.13％,gram-negative bacteria accounted for 64.38％and fungi accounted for 15.69％.The top 5 isolates were Escherichia coli(1846 strains,34.94％),Klebsiella pneumoniae(515 strains,9.75％),Candida albicans(449 strains,8.50％),Enterococcus faecalis(394 strains,7.46％)and Enterococcus faecium(388 strains,7.34％).From April 2021 to April 2023,the resistance rates of Escherichia coli to Imipenem were 0.76％.The resistance rates of Klebsiella pneumoniae to Imipenem was 4.78％.The resistance rates of Acinetobacter baumannii to Imipenem was 49.06％.The drug resistance rates of Pseudomonas aeruginosa to Imipenem was 5.81％.Conclusion:Enterococcus,Escherichia coli and Candida albicans were the main pathogens of urinary tract infection in this hospital.Carbapenem-resistant Klebsiella pneumoniae and Acinetobacter baumannii had high detection rates,which should be paid more attention in clinical practice.
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