Objective:To investigate the effect of clopidogrel combined with aspirin(ASP)on serum high-sensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6),and tumour necrosis factor-related protein 3(CTRP3)levels in patients with acute cerebral infarction(ACI).Methods:-90 ACI patients were collected(from January 2022 to December 2023)in our hospital and divided into group A(n=45)and group B(n=45)according to treatment regimen.Group B received ASP treatment,while group A received clopidogrel combined with ASP treatment.Compare the total effective rate and levels of the National Institutes of Health Stroke Scale(NIHSS),Montreal Cognitive Assessment Scale(MoCA),hemorheology[whole blood low cut viscosity(LBV),whole blood mid cut viscosity(WBV),whole blood high cut viscosity(HBV),plasma viscosity(PV)],nerve injury factors[neuron-specific enolase(NSE),matrix metalloproteinase-9(MMP-9),central nervous system-specific protein(S-100β)],serum high sensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6),tumor necrosis factor associated protein 3(CTRP3)before and after treatment between the two groups,as well as the incidence of adverse reactions during treatment.Results:The total effective rate of group A was 93.33％(42/45)higher than group B 75.56％(34/45)(P＜0.05);NIHSS score was lower and MoCA score was higher in group A than in group B after 14 d of treatment(P＜0.05);LBV,WBV,HBV,PV levels were lower in group A than in group B after 14 d of treatment(P＜0.05);Serum NSE,MMP-9,S-100β expression was lower in group A than in group B after 14 d of treatment(P＜0.05).The expression of serum NSE,MMP-9 and S-100β in group A was lower than that in group B after 14 d of treatment(P＜0.05);After 14 days of treatment,the serum levels of hs CRP and IL-6 in group A were lower than those in group B,while the serum levels of CTRP3 were higher than those in group B(P＜0.05);There was no significant difference in the incidence of adverse reactions between the 2 groups compared with each other(P＞0.05).Conclusion:The combination of clopidogrel and ASP has a significant effect on treating ACI patients,which can effectively alleviate the inflammatory state of the body,reduce nerve damage,regulate blood theology levels,improve neurological and cognitive functions,and has high drug safety.
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