Objective:To understand the infection situation and serotype of salmonella in diarrhea cases in our hospital,so as to provide scientific basis for effective prevention and treatment of salmonella infection,formulation of prevention strategy and clinical medication in this area.Methods:The fecal samples of 833 suspected bacterial diarrhea cases from a third-class hospital in Shandong province were cultured,isolated and identified,and their clinical distribution characteristics were analyzed.Results:A total of 40 cases(4.8%)of salmonella infection were detected in 833 cases,and the positive rate was statistically significant in different seasons(x2=8.428,P<0.05).There was no significant difference in sex,age,occupation,household registration,antibiotic use before treatment and salmonella detection in 40 patients with salmonella infection(P>0.05).Compared with single infection,the incidence of abdominal pain,nausea,vomiting and fever in mixed infection was higher,and the difference was statistically significant(P<0.05).There are 8 serotypes of salmonella isolated,mainly Salmonella enteritis(30%)and Salmonella typhimurium(50%),which are the dominant serotypes.Conclusion:Salmonella infection mostly occurs in summer and autumn in a county of Shandong province.Health education can be carried out for key groups in the high incidence season,behavioral intervention measures can be made to reduce the incidence of salmonella infection and timely treatment of patients with salmonella infection.