利培酮和齐拉西酮对精神分裂症病人血浆CK影响
THE INFLUENCE OF RISPERIDONE AND ZIPRASIDONE ON PLASMA CYTOKINE IN PATIENTS WITH SCHIZOPHRENIA
薛晓斌 1缪竞诚2
作者信息
- 1. 苏州大学基础医学与生物科学学院细胞与分子生物学教研室,江苏苏州215100;青岛市精神卫生中心六病房
- 2. 苏州大学基础医学与生物科学学院细胞与分子生物学教研室,江苏苏州215100
- 折叠
摘要
目的 观察精神分裂症病人血浆细胞因子(CK)水平的变化,探讨利培酮和齐拉西酮对病人CK水平的影响.方法 采用酶联免疫吸附法,检测50例精神分裂症病人治疗前后白细胞介素-2(IL-2)、白细胞介素-6(IL6)和肿瘤坏死因子α(TNF-α)水平,以50名健康人作为对照.结果 治疗前后利培酮和齐拉西酮组IL-2、IL-6和TNF-α的水平均高于正常对照组,差异有显著性(F=74.73～140.53,q=14.72～45.06,P＜0.01)；经利培酮及齐拉西酮治疗8周后,IL-2、IL-6和TNF-a水平均明显降低,与治疗前比较差异有显著意义(t=3.34～19.43,P＜0.01).结论 精神分裂症存在CK介导的免疫功能障碍,利培酮和齐拉西酮对CK具有调节作用.
Abstract
Objective To observe plasma cytokine and influence of Risperidone and Ziprasidone on it in patients with schizophrenia. Methods By employing ELISA, the levels of IL-2, IL-6 and TNF-o in 50 patients with schizophrenia-before and after therapy-were detected, and 50 healthy individuals were served as the control. Results The levels of IL-2, IL-6 and TNF-o in the patients, both before and after treatment with Risperidone and Ziprasidone, were higher than that in the control, showing a significant difference among them (F=74. 73-140. 53,g=14. 72 - 45. 06,P<0. 01). After eight weeks treated with the two drugs, the levels of IL-2, IL-6 and TNF-a decreased versus before medication (t-3. 34 -19. 43,P<0. 01). Conclusion There is a cytokine-mediated immune dysfunction in patients with schizophrenia, Risperidone and Ziprasidone manifest accommodation on the level of cytokine.
关键词
精神分裂症/利培酮/齐拉西酮/白细胞介素2/白细胞介素6/肿瘤坏死因子αKey words
schizophrenia) Resperidone/Ziprasidone/interleukin-2/interleukin-6/tumor necrosis factor-alpha引用本文复制引用
出版年
2011
NETL
NSTL
维普
万方数据