摘要
目的 探讨食管鳞状细胞癌组织内皮素-1和E-钙黏蛋白的表达水平,并分析两者之间关系.方法 应用免疫组织化学技术,检测58例食管鳞癌组织及相应癌旁正常食管组织内皮素-1和E-钙黏蛋白的表达情况.结果 食管鳞癌组织内皮素-1和E-钙黏蛋白的阳性表达与浸润深度、周围淋巴结转移与否、分化程度有关(Z=6.908～14.973,P＜0.05);食管鳞癌组织和相应癌旁正常食管组织中内皮素-1的阳性表达率分别为12.07％(7/58)和77.59％(45/58),E-钙黏蛋白的阳性表达率分别为82.76％(48/58)和41.38％(24/58),两组两种指标比较差异有显著性(Z=-7.161、-5.593,P＜0.01).食管鳞癌组织内皮素-1和E-钙黏蛋白表达呈负相关(r=-0.525,P＜0.01).结论 食管鳞癌组织中内皮素-1呈高表达、E-钙黏蛋白呈低表达,二者对食管鳞癌的发生发展可能存在反向调节作用.
Abstract
Objective To investigate the expressions of Endothelin-1 (ET-1) and E-cadherin,and their correlation,in esophageal squamous cell carcinoma (ESCC).Methods Employing immuno-histochemical technique,expressions of Endothelin-1 and E-cadherin in 58 cases of ESCC tissue and corresponding adjacent normal mucosa were detected.Results In the cancer tissue,expressions of ET-1 and E-cadherin were correlated with invasion depth,peripheral lymph node metastasis,and differentiation degree (Z=6.908-14.973,P＜0.05).The positive expression of ET1 in tissue of ESCC and adjacent normal tissue was 12.07％ (7/58) and 77.59％ (45/58),respectively,and that of E-cadherin was 82.76％ (48/58) and 41.37％ (24/58),respectively,a comparison between the two indicators of the two groups being significant (Z=-7.161,-5.593;P ＜ 0.01).In tissue of ESCC,ET-1 expression was negatively correlated with E-cadherin (r=-0.525,P＜0.01).Conclusion In tissue of esophageal squamous cell cacinoma,the high expression of ET-1 and low expression of E-cadherin are likely to play an opposite regulation on the occurrence and development of ESCC.
NETL
NSTL
维普
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