EXPRESSION OF MIR-19B-1-5P IN TISSUES OF BENIGN PROSTATIC HYPERPLASIA AND PROSTATE CANCER
Objective To investigate the expression of microRNA (miRNA,miR)-19b-1-5p in benign prostatic hyperplasia (BPH) and prostate cancer (PCa) and analyze its association with clinicopathology.Methods The expression levels of 68 BPH tissues and 77 PCa tissues were detected using real-time quantitative polymerase chain reaction (Real-time PCR) and its correlation with Gleason Grading and clinical characters were analyzed.Results Employing real time fluorescent quantitative polymerase chain reaction technique,the expression of miR 19b-1-5p in 68 cases of BPH tissue and 77 cases of prostate cancer tissue was detected,and the association of relative expression of miR-19b 1-5p with Gleason Grade and clinical features of the cancer was analyzed (t=13.08,7.55;P<0.05).Conclusion miR 19b-1-5p may be used as a potential biomarker in early diagnosis of pros tate cancer and its prognosis evaluation.