术前中性粒/淋巴细胞比值在上尿路尿路上皮癌病人预后评估中的价值
PREOPERATIVE NEUTROPHIL-LYMPHOCYTE RATIO: ITS VALUE IN PREDICTING PROGNOSIS OF PATIENTS WITH UPPER URINARY TRACT UROTHELIAL CARCINOMA
宋鑫 1马志鹏 2俞程程 1柴东岳 1李斌 1孙立江1
作者信息
- 1. 青岛大学附属医院泌尿外科,山东青岛266003
- 2. 潍坊市益都中心医院泌尿外科
- 折叠
摘要
目的 探讨术前中性粒细胞/淋巴细胞比值(NLR)在上尿路尿路上皮癌(UUTUC)病人预后评估中的价值.方法 回顾性分析手术治疗的105例UUTUC病人的临床病理资料,分析NLR与病人临床病理特征之间的关系,比较高低NLR病人肿瘤特异性生存率和无复发生存率差异.应用Kaplan-Meier法和Log-rank检验进行生存分析,应用Cox比例风险回归模型进行独立危险因素分析.结果 术前高NLR(NLR≥1.90)组病人病理T分期高于低NLR(NLR＜1.90)组,差异有统计学意义(x 2=8.181,P＜0.05),术前低NLR组病人肿瘤特异性生存率和无复发生存率高于高NLR组,差异有统计学意义(x 2=11.591、18.205,P＜0.05).病理T分期、术前NLR是影响病人肿瘤特异性生存率和无复发生存率的独立危险因素(OR =0.095～0.266,P＜0.05).结论 术前NLR是影响U UTUC病人预后的独立危险因素,可用于评估UUTUC病人预后.术前NLR≥1.90病人预后差.
Abstract
Objective To assess the value of preoperative peripheral blood neutrophil-lymphocyte ratio (NLR) in predicting the prognosis of patients with upper urinary tract urothelial carcinoma (UUTUC).Methods Clinical data of 105 patients with UUTUC treated by surgery were retrospectively reviewed.The association of NLR with clinicopathological features was analyzed.The differences in cancer-specific survival (CSS) rate and recurrence-free survival (RFS) rate between high-NLR and lowNLR groups were compared.A survival analysis was conducted using Kaplan-Meier method and Log-rank test.An independent risk factor analysis was conducted using Cox proportional-hazards regression model.Results Pathological T staging was higher in patients with high preoperative NLR (NLR ≥1.90) than that in patients with low NLR (NLR＜1.90),the difference was significant (x2=8.181,P ＜0.05).In low N LR group,the CSS and RFS rates were higher than that in the high-NLR group (x2 =11.591,18.205;P＜0.05).Pathological T staging and preoperative NLR were the independent risk factors for CSS and RFS (OR =0.095-0.266,P＜0.05).Conclusion The preoperative neutrophil-lymphocyte ratio is an independent risk factor for the prognosis of patients with upper urinary tract urothelial carcinoma,it can be used to predict the prognosis of patients with this malignancy.The prognosis of patients with preoperative NLR ≥1.90 is poor.
关键词
泌尿系肿瘤/中性粒细胞-淋巴细胞比/预后/上尿路尿路上皮癌Key words
urologicneoplasms/neutrophil-lymphocyte ratio/prognosis/upper urinary tract urothelial carcinoma引用本文复制引用
出版年
2017
NETL
NSTL
维普
万方数据