THE VALUE OF PROCALCITONIN AND SICAM-1 IN EARLY PREDICTING THE SEVERITY OF ACUTE PANCREATITIS
Objective To evaluate the clinical significance of serum procalcitonin (PCT) and soluble intercellular adhesion molecule-1 (sICAM-1) in early prediction of severity of acute pancreatitis (AP).Methods Sixty two patients with AP were selected,among them,22 were moderate and severe AP (MSAP),10 were severe AP (group A),and 30 were mild AP (group B).APACHE Ⅱ and Ranson system were used to score the conditions of patients in the two groups.PCT and sICAM were detected.The correlation of serum PCT and sICAM-1 with Ranson score and APACHE Ⅱ score was analyzed.The diagnostic efficiency of PCT and sICAM-1 for AP was evaluated using receiver operating characteristic curve (ROC).Results On the first day of admission,serum levels of PCT and sICAM 1 in group A were higher than that in group B (t=9.36,7.63;P＜0.05).On days 1,4and 7 of admission,the levels of serum PCT and sICAM-1 gradually decreased with the increase of time (F =19.65-33.58,P ＜0.05).On days 1,4 and 7 of admission,serum levels of PCT and sICAM 1 in group A were higher than that in group B,the difference was significant (t =7.63-13.90,P ＜0.05).The level of serum PCT and sICAM-1 were positively correlated with Ranson and APACHE Ⅱ scores (r=0.493 0.726;P＜0.05);the ROC curve analysis revealed the AUC of serum sICAM-1 and PCT was 0.971 and 0.863,respectively;the sensitivity of PCT and sICAM 1 in the diagnosis of SAP was 87.35％ and 69.32％,respectively;the specificity was 98.67％ and 90.36％,respectively.Conclusion Combined detection of serum sICAM-1 and PCT can effectively predict the severity of acute pancreatitis,and provide the basis for the development of its treatment program.
NETL
NSTL
万方数据
维普
