PREEMPTIVE ANALGESIA OF FLURBIPROFEN AXETIL COMBINED WITH DIFFERENT DOSES OF SUFENTANIL FOR POST-OPERATIVE ANALGESIA IN CHILDREN UNDERGOING PELVIC OSTEOTOMY: COMPARISON OF ANALGESIC EFFECT
Objective To evaluate the effect of preemptive analgesia of flurbiprofen axetil combined with different doses of sufentanil on children after pelvic osteotomy and look for the mode of postoperative analgesia in children.Methods Ninety children-three to 10-year old-scheduled for elective innominate osteotomy under general anesthesia were enrolled and evenly randomized to three groups as N1,N2 and N3.Before skin incision,an intravenous injection of flurbiprofen axetil (1 mg/kg) was given to patients in the three groups for preemptive analgesia,and the doses of sufentanil in patient-controlled analgesia (PCA) were 1.5 μg/kg for N1,2.0 μg/kg for N2,and 2.5 μg/kg for N3,respectively.The content of ondansetron in each PCA pump was 0.1 mg/kg plus normal saline to 100 mL.Extubation time in anesthesia recovery room of the sick kids in each group was recorded.Postoperative FLACC score and Ramsay sedation score of 2,4,8,12,24 and 48 h were made,and the times of PCA press within 48 hours after surgery,as well as untoward effects such as nausea,vomiting and respiratory depression were recorded.Results The difference in postoperative extubation time in sick kids among the three groups were not significant (P＞0.05).FLACC score showed that four,eight and 12 hours after surgery,the score of sick kids in groups N2 and N3 was lower than that in group N1 and that in group N3 was lower than that in group N2,the differences being statistically significant (F-3.664 84.558,P＜0.05);the score of 24 and 48 hours in group N3 after surgery was lower than that in group N1 (F 4.225,8.667;P ＜0.05).As for Ramsay score,the score of groups N2 and N3 was higher than that in group N1-four,eight and 12 hours after surgery (F=5.36724.996,P＜0.05);and 24 and 48 hours after surgery,the score of group N3 was higher than that of group N1 (F=14.073,6.074;P ＜0.05).Concerning times of PCA button pressing,13 times in group N1,seven times in group N2 and three times in group N3,the difference was statistically significant (x 2=6.410,P ＜0.05).The incidence of side effects was significantly higher in group N3 compared with groups N1 and N2 (x2 =7.587,P＜0.05).Conclusion Preemptive analgesia of flurbiprofen axetil (1 mg/kg)combined with sufentanil (2.0 μg/kg) is an ideal mode of patient-controlled analgesia for innominate osteotomy in children.
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维普
