DIFFERENT VOLUME CATHETER THROMBOLYSIS FOR ACUTE DEEP VENOUS THROMBOSIS OF LOWER EXTREMITY
Objective To investigate the efficacy of different volume catheter thrombolysis in the treatment of acute central deep venous thrombosis (ACDVT) of lower extremity.Methods Eighty patients with ACDVT were evenly randomized to high-volume group and low-volume group.Under filter protection,the infusion catheter was implanted and contact thrombolytic therapy carried out.Continuous infusion of heparin was conducted through indwelling sheath tube in popliteal vein of affected lower limb.In low-volume group,urokinase 100 kU+physiologieal saline 50 mL were given,and in high-volume group,urokinase 100kU+ physiological saline 250 mL were given.Urokinase was sprayed every four hours in both groups through a thrombolytic catheter.In the process of thrombolysis,coagulation function was monitored in both groups.The recanalization rate of external iliac and femoral vein,urokinase dosage and complications between the two groups were compared.Results In high-volume group,the vascular recanalization rate was higher higher than that in the low-volume group and the dosage of urokinase was lower (t =2.33,3.05;P＜0.05).Conclusion The efficacy of high volume urokinase thrombolytic therapy for acute central deep venous thrombosis of lower extremity is significant.
NETL
NSTL
万方数据
维普
