不同容量导管溶栓对急性期下肢深静脉血栓形成效果
DIFFERENT VOLUME CATHETER THROMBOLYSIS FOR ACUTE DEEP VENOUS THROMBOSIS OF LOWER EXTREMITY
张利 1李想 1吴华平1
作者信息
- 1. 达州市中心医院心脏血管外科,四川达州635000
- 折叠
摘要
目的 探讨不同容量导管溶栓治疗急性中央型下肢深静脉血栓形成的效果.方法 急性中央型下肢深静脉血栓病人80例,随机分为高容量组和低容量组,两组均在滤器保护下植入溶栓导管行接触性溶栓治疗,通过患肢腘静脉留置鞘管持续泵入肝素,低容量组给予尿激酶100 kU+生理盐水50 mL,高容量组给予尿激酶100 kU+生理盐水250mL,两组均每4h通过溶栓导管脉冲喷洒尿激酶,溶栓治疗过程中监测凝血功能.比较两组髂外及股静脉血管再通率、尿激酶用量及并发症发生情况.结果 高容量组血管再通率高于低容量组,尿激酶用量少于低容量组,差异有显著性(t =2.33、3.05,P＜0.05).结论 高容量导管接触溶栓治疗急性中央型下肢深静脉血栓形成效果显著.
Abstract
Objective To investigate the efficacy of different volume catheter thrombolysis in the treatment of acute central deep venous thrombosis (ACDVT) of lower extremity.Methods Eighty patients with ACDVT were evenly randomized to high-volume group and low-volume group.Under filter protection,the infusion catheter was implanted and contact thrombolytic therapy carried out.Continuous infusion of heparin was conducted through indwelling sheath tube in popliteal vein of affected lower limb.In low-volume group,urokinase 100 kU+physiologieal saline 50 mL were given,and in high-volume group,urokinase 100kU+ physiological saline 250 mL were given.Urokinase was sprayed every four hours in both groups through a thrombolytic catheter.In the process of thrombolysis,coagulation function was monitored in both groups.The recanalization rate of external iliac and femoral vein,urokinase dosage and complications between the two groups were compared.Results In high-volume group,the vascular recanalization rate was higher higher than that in the low-volume group and the dosage of urokinase was lower (t =2.33,3.05;P＜0.05).Conclusion The efficacy of high volume urokinase thrombolytic therapy for acute central deep venous thrombosis of lower extremity is significant.
关键词
深静脉血栓形成/机械溶栓/尿激酶型纤溶酶原激活物Key words
venous thrombosis/mechanical thrombolysis/urokinase-type plasminogen activator引用本文复制引用
出版年
2017
NETL
NSTL
维普
万方数据