CLINICAL SIGNIFICANCE OF IMPULSE OSCILLOMETRY AND PERIPHERAL BLOOD EOS DETECTION IN THE TREATMENT OF CHILDHOOD ASTHMA
Objective To discuss the clinical significance of impulse oscillometry (IOS) and peripheral blood EOS detection in the treatment of childhood asthma.Methods Eighty-seven children with bronchial asthma (BA) initially diagnosed in our asthma clinic-March-November 2016-were selected to serve as asthma group.Peripheral blood EOS ratio was measured,and IOS test done.And,at the same time,a routine pulmonary function test (PFT) was performed in 42 sick kids of more than sixyear old.The above parameters were retested after (60±15) days of standardized treatment.Another 80 healthy children were selected and served as control group,all of them received EOS and IOS as that done in the asthma group,and PTF was done in 40 children of above six year old.Results Before treatment,total respiratory impedance (Z5),total respiratory viscosity resistance (Rs),central airway viscosity resistance (R20),peripheral airway viscosity resistance (R5-R20),peripheral elastic resistance (X5)and peripheral blood EOS were higher than that after treatment in the asthma group and that of control group,and after treatment,the above parameters in the asthma group were still higher than that of the control group (F=30.470-401.793,P＜0.01).In the asthma group,forced expiratory volume (FEV1),maximal expiratory flow in 50％ vital capacity (FEF50),maximal expiratory flow in 75 ％ vital capacity (FEF75),maximal midexpiratory flow (MMEF75/25) before treatment were obviously lower than that after treatment and that of control group,FEV1 after treatment was still lower than that of the control group (F=5.318-8.878,P＜0.05).Before treatment,the Z5 was negatively correlated with FVC (r=-0.598,P＜0.01),R5-R20 was negatively correlated with FEF25,FEF50,and FEF75 (r=-0.651--0.536,P＜0.01);X5 was positively correlated with FEF25,FEF50,FEF75,and MMEF75/25 (r=0.528-0.625,P＜0.01).Conclusion IOS and PFT have very good correlation.Detections of IOS and PFT as well as peripheral blood eosinophils count ratio have important clinical significance in evaluation of children-especially for preschool children with asthma and in treatment of the disease.
respiratory function testseosinophilic granulocytechildasthmatherapy
NETL
NSTL
万方数据
维普
