FISH CONSUMPTION AND RISK OF CARDIOVASCULAR DISEASE MORTALITY: A DOSE-RESPONSE META-ANALYSIS
Objective To investigate the association of fish consumption with risk of cardiovascular disease (CVD) mortality.Methods A systematic literature search was performed in PubMed,EMBASE,Web of science,Wanfang and Chinese National Knowledge Infrastructure databases up to September 2016-all the Chinese and English literature on the relationship between fish intake and risk of death from CVD was collected.Adopting random effects model,the pooled RR and 95％CI were selected and calculated.The restricted cubic spline model was applied to assess the dose-response relationship.Results A total of 14 prospective cohort studies with 487 442 participants were included in this meta-analysis.For the highest versus the lowest consumption of fish,the pooled RR was 0.91 (95 ％ CI =0.85-0.96).The dose-response analysis indicated a nonlinear relationship between fish consumption and CVD mortality (P=0.041).Conclusion High fish consumption may be associated with the reduced risk of cardiovascular disease mortality.
NETL
NSTL
万方数据
维普
