EXPRESSION AND SIGNIFICANCE OF OSTEOPONTIN AND CD133 IN TISSUES OF OVARIAN EPITHELIAL CARCINOMA
Objective To investigate the expression and biological significance of osteopontin (OPN) and CD133 in the tissues of ovarian epithelial carcinoma.Methods Immunohistochemistry was used to measure the expression of OPN and CD133 in tissues of ovarian cancer,borderline ovarian tumor,benign ovarian tumor,and normal ovary.Results The positive expression levels of OPN and CD133 in ovarian cancer tissues were significantly different from those in tissues from normal ovary,benign tumor,and borderline ovarian tumor (x2 =23.45,35.96;q=-8.24--3.82;P＜0.05).However,the positive expression levels of OPN and CD133 in normal tissues were not significantly different from those in benign tumor tissue (P＞0.05).Positive expression of OPN and CD133 was correlated with clinical stage of ovarian cancer,degree of tumor differentiation,and lymph node metastasis (x2 =4.19-12.10,P＜0.05),and had nothing to do with the histological type of ovarian cancer (P＞0.05).In ovarian tissue,the expression of OPN was positively correlated with CD133 expression (r=0.525,P＜0.05).Conclusion The synergistic effect between OPN and CD133 may play an important role in ovarian cancer development.The relationship between their expression in ovarian cancer tissue can provide a guidance for the clinical diagnosis and treatment.
NETL
NSTL
万方数据
维普
