IMAGING CHARACTERISTICS OF SARCOIDOSIS AND NHL INVOLVING MEDIASTINAL LYMPH NODES ON 18 F-FDG PET/CT
Objective To evaluate the imaging characteristics of sarcoidosis and non-Hodgkin's lymphoma (NHL) involving mediastinal lymph nodes on 18F-FDG PET/CT and CT.Methods The 18F-FDG PET/CT and plain thoracic CT images of 30 thoracic sarcoidosis patients and 35 NHL patients,who had a confirmed diagnosis by pathological examination or clinical follow up,were retrospectively analyzed.The distribution,sizes,density,boundary,and maximum standard uptake value (SUVmax) of those lymph nodes were compared between the two groups of patients.Results NHL was more likely to involve the mediastinal lymph nodes in 3a,3p,and bilateral supradiaphragmatic space than sarcoi-dosis.There were significant differences between sarcoidosis and NHL in the distribution (symmetrical or asymmetrical),boundary (clear or unclear),and density (homogeneous or inhomogeneous) of the involved thoracic lymph nodes (x2 =20.411-56.826,P＜0.01).There was no significant difference in the presence or absence of calcification in the involved lymph nodes between sarcoidosis and NHL (P＞0.05).There was a significant difference in the maximum diameter of the involved thoracic lymph nodes between sarcoidosis and NHL (t =2.56,P＜0.05).There was no significant difference in the SUVmax of the involved lymph nodes between sarcoidosis and NHL (P＞0.05).Conclusion We cannot differentiate between sarcoidosis and NHL involving mediastinal lymph nodes based on the metabolic status on 18F-FDG PET/CT.However,sarcoidosis and NHL tend to involve the thoracic lymph nodes located in different regions;the lymph nodes involved in NHL have asymmetrical distribution,inhomogeneous density,and unclear boundary,and have a larger maximum diameter than those involved in sarcoidosis.
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